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Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis.降钙素原、C反应蛋白、白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α在新生儿败血症诊断中的作用
Turk J Pediatr. 2007 Jan-Mar;49(1):7-20.
2
Early diagnosis of bacterial infection in the neonate.新生儿细菌感染的早期诊断
J Matern Fetal Neonatal Med. 2004 Nov;16 Suppl 2:13-6. doi: 10.1080/14767050410001727116.
3
Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis.细胞因子（白细胞介素-1β、6、8、肿瘤坏死因子-α以及白细胞介素-2可溶性受体）和C反应蛋白在新生儿败血症诊断中的作用。
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4
Utility of haematological parameters and C-reactive protein in the detection of neonatal sepsis.血液学参数和C反应蛋白在新生儿败血症检测中的效用
J Paediatr Child Health. 2002 Oct;38(5):459-64. doi: 10.1046/j.1440-1754.2002.00018.x.
5
Interleukin-8: a valuable tool to restrict antibiotic therapy in newborn infants.白细胞介素-8：限制新生儿抗生素治疗的一项重要工具。
Acta Paediatr. 2001 Sep;90(9):1025-32. doi: 10.1080/080352501316978110.
6
Reactive hyperemia and interleukin 6, interleukin 8, and tumor necrosis factor-alpha in the diagnosis of early-onset neonatal sepsis.反应性充血及白细胞介素6、白细胞介素8和肿瘤坏死因子-α在早发型新生儿败血症诊断中的应用
Pediatrics. 2001 Oct;108(4):E61. doi: 10.1542/peds.108.4.e61.
7
Serial interleukin 6 measurements in the early diagnosis of neonatal sepsis.连续检测白细胞介素6在新生儿败血症早期诊断中的应用
J Trop Pediatr. 2000 Oct;46(5):267-71. doi: 10.1093/tropej/46.5.267.
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Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms.脓毒症早产儿和健康早产儿的血浆粒细胞巨噬细胞集落刺激因子及白细胞介素-6浓度
Eur J Pediatr. 2000 Mar;159(3):156-7. doi: 10.1007/s004310050041.
9
Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections.以白细胞介素-8和C反应蛋白作为细菌感染标志物减少新生儿不必要的抗生素治疗
Pediatrics. 1999 Sep;104(3 Pt 1):447-53. doi: 10.1542/peds.104.3.447.
10
Outcome prediction by traditional and new markers of inflammation in patients with sepsis.脓毒症患者中传统和新型炎症标志物对预后的预测
Clin Chem Lab Med. 1999 Mar;37(3):363-8. doi: 10.1515/CCLM.1999.060.

血清白细胞介素-1β、白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α水平在新生儿败血症早期诊断与管理中的作用

Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis.

作者信息

Kurt A Nese Citak, Aygun A Denizmen, Godekmerdan Ahmet, Kurt Abdullah, Dogan Yasar, Yilmaz Erdal

机构信息

Department of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, Turkey.

出版信息

Mediators Inflamm. 2007;2007:31397. doi: 10.1155/2007/31397.

DOI:10.1155/2007/31397
PMID:18274637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2220039/
Abstract

AIM

To determine serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up.

METHODS

This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17).

RESULTS

At the time of diagnosis, serum IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1beta, IL-6, IL-8, and TNF-alpha levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment.

CONCLUSION

Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.

摘要

目的

测定新生儿败血症诊断时及治疗后的血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平，并显示其在随访中的意义。

方法

本前瞻性研究对因新生儿败血症住院的新生儿进行，这些新生儿被分为确诊败血症组（n = 12）、培养阴性败血症组（n = 21）和健康新生儿组（n = 17）。

结果

诊断时，确诊败血症组的血清IL-1β、IL-6、IL-8和TNF-α水平显著高于对照组（P <.05）。诊断时，确诊败血症组和培养阴性败血症组的IL-1β、IL-6、IL-8和TNF-α水平显著高于抗生素治疗后第7天的水平。

结论

血清IL-1β、IL-6、IL-8和TNF-α是炎症介质，可用于新生儿败血症的诊断和治疗效果评估。