Esposito Mark, Ganesan Shridar, Kang Yibin
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Nat Cancer. 2021 Mar;2(3):258-270. doi: 10.1038/s43018-021-00181-0. Epub 2021 Mar 24.
The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis. Here we discuss recent advances in our understanding of tumor-intrinsic pathways driving metastatic colonization and therapeutic resistance, as well as immune activating strategies to target metastatic disease. We focus on therapeutically exploitable mechanisms, promising strategies in preclinical and clinical development, and emerging areas with potential to become innovative treatments.
肿瘤细胞的全身扩散是大多数癌症死亡的最终原因，但针对转移的特异性治疗策略却很少成功出现。在此，我们讨论了在理解驱动转移定植和治疗抗性的肿瘤内在途径方面的最新进展，以及针对转移性疾病的免疫激活策略。我们关注可用于治疗的机制、临床前和临床开发中的有前景的策略，以及有可能成为创新疗法的新兴领域。
