硫酸镁：急诊科快速心房颤动管理的辅助治疗方法，在治疗开始的 1 小时内。
Magnesium Sulfate: an adjunctive therapy in the first hour of management of rapid atrial fibrillation in the emergency department.
出版信息
Tunis Med. 2021 Feb;99(2):225-231.
INTRODUCTION
Rapid Atrial fibrillation (AF) is a common arrhythmia in emergency department (ED) that requires an urgent control of ventricular rate.
AIM
To evaluate the safety and efficiency of magnesium sulfate as an adjunctive therapy in addition to usual care for rapid AF in emergency department.
METHODS
This was a prospective, randomized, double-blind study. We included patients who presented to ED with rapid AF >110 batt/min. Group A received 3g of magnesium in 100mL of glucose solution and group B received 100 ml of glucose solution. Primary endpoint was slowing the ventricular rates to less than 110 beats/ min in the first 12 hours of management.
RESULTS
One hundred and three patients were included. Fifty-three patients in group A with a mean heart rate of 146 ± 18 beats / min and fifty patients in group B with a mean heart rate of 143 ± 17 beats / min. A significantly greater number of patients slowed down their ventricular rate in group A during the first hour of management (p = 0.02). After 12 hours, mean heart rate was significantly lower in group A (p = 0.04).
CONCLUSION
The use of 3 g of magnesium sulfate slowed down the ventricular rate of a larger number of patients with rapid AF in the first hour of management. Only minor adverse effects were registered.
简介
快速性心房颤动（AF）是急诊科常见的心律失常，需要紧急控制心室率。
目的
评估硫酸镁作为附加治疗在急诊科快速性 AF 中的安全性和有效性。
方法
这是一项前瞻性、随机、双盲研究。我们纳入了以快速性 AF >110 次/分就诊于急诊科的患者。A 组给予 3g 硫酸镁溶于 100ml 葡萄糖溶液，B 组给予 100ml 葡萄糖溶液。主要终点是在管理的前 12 小时内将心室率降至 110 次/分以下。
结果
共纳入 103 例患者。A 组 53 例，平均心率 146±18 次/分；B 组 50 例，平均心率 143±17 次/分。在管理的第一个小时内，A 组有更多的患者心室率减慢（p=0.02）。12 小时后，A 组平均心率明显降低（p=0.04）。
结论
使用 3g 硫酸镁可在管理的第一个小时内使更多的快速性 AF 患者的心室率减慢。仅记录到轻微的不良反应。
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