COPD 患者的身体组成及其对肺功能的影响。
COPD patients' body composition and its impact on lung function.
出版信息
Tunis Med. 2021 Feb;99(2):285-290.
INTRODUCTION
Despite fat-free mass index (FFMI) is one of the strongest predictive factors of survival during chronic obstructive pulmonary disease (COPD), there is a considerable lack of information regarding body composition in Tunisian patients with COPD. Aim: Describe the body composition of Tunisian patients followed for COPD and examine the relationship between body composition and the severity of the disease.
METHODS
Cross-sectional study of patients with stable COPD. Body composition was assessed by bioelectrical impedance analysis. Pulmonary function tests (PFT) included spirometry with plethysmography and the six-minute walking test. The severity of dyspnea was assessed by the mMRC scale.
RESULTS
During the study period, 104 patients with stable COPD were included (average age= 65.9 years and average FEV1= 49.3%). Fifty-four percent of patients were GOLD D stage. According to the IMM, malnutrition was identified in 20.2% of cases. Patients with low FFMI were the most symptomatic, had a more severe air flow limitation and a more severe disease. The walking distance was lower in malnourished patients. However, FFMI was not significantly associated with exercise capacity.
CONCLUSIONS
Malnutrition is highly prevalent in COPD patients and is correlated to the severity of the disease. Thus, body composition analysis should be considered in COPD patient management.
简介
尽管去脂体重指数（FFMI）是预测慢性阻塞性肺疾病（COPD）患者生存的最强预测因素之一，但关于 COPD 患者的身体成分，突尼斯的数据仍相当缺乏。目的：描述接受 COPD 治疗的突尼斯患者的身体成分，并研究身体成分与疾病严重程度之间的关系。
方法
这是一项稳定期 COPD 患者的横断面研究。通过生物电阻抗分析评估身体成分。肺功能测试（PFT）包括体描法肺量计和六分钟步行试验。呼吸困难的严重程度通过 mMRC 量表评估。
结果
在研究期间，共纳入 104 例稳定期 COPD 患者（平均年龄=65.9 岁，平均 FEV1=49.3%）。54%的患者处于 GOLD D 期。根据 IMM，20.2%的病例存在营养不良。低 FFMI 的患者症状最严重，气流受限更严重，疾病更严重。营养不良患者的步行距离更短。然而，FFMI 与运动能力无显著相关性。
结论
COPD 患者中营养不良的发生率很高，且与疾病的严重程度相关。因此，在 COPD 患者的管理中应考虑身体成分分析。
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