Center for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
J Clin Exp Neuropsychol. 2021 Apr;43(3):290-300. doi: 10.1080/13803395.2021.1917523. Epub 2021 Apr 26.
: The Learning Ratio (LR) is a novel learning slope score that has been developed to reduce the inherent competition between the first trial and subsequent trials in traditional learning slopes. Recent findings suggest that LR is sensitive to AD pathology along the AD continuum - more so than the traditional learning calculations that employ raw changes across trials. However, research is still experimental and not yet directly applicable to clinical settings. Consequently, the objective of the current study was to develop demographically-corrected normative data on these LR learning slopes.: The current study examined the influence of age and education on LR scores for the HVLT-R, BVMT-R, and an Aggregated HVLT-R/BVMT-R in 200 cognitively intact adults aged 65 years and older using linear regression.: Age negatively correlated with all LR metrics, and education positively correlated with most. No sex differences were identified. LR values were predicted from age and education, which can be compared to observed LR values and converted into demographically-corrected scores.: By comparing observed and predicted LR scores calculated from regression-based prediction equations, interpretations are permitted that aid in clinical decision making and treatment planning. Co-norming of the HVLT-R and BVMT-R also allows for comparisons between verbal and visual learning slope scores in individual patients. We hope normative data for LR enhances its utility as a clinical tool for examining learning slopes in older adults administered the HVLT-R and/or BVMT-R.
学习率(LR)是一种新的学习斜率评分,旨在减少传统学习斜率中首次试验与后续试验之间固有的竞争。最近的研究结果表明,LR 能够敏感地反映 AD 病理沿 AD 连续谱的变化——比传统的学习计算方法更能反映出试验之间的原始变化。然而,研究仍处于实验阶段,尚未直接适用于临床环境。因此,本研究的目的是为 HVLT-R、BVMT-R 和 HVLT-R/BVMT-R 这三种认知测试的 LR 学习斜率制定经过人口统计学校正的正常数据。
本研究使用线性回归分析,对 200 名认知正常的 65 岁及以上老年人的 HVLT-R、BVMT-R 和综合 HVLT-R/BVMT-R 的年龄和教育对 LR 分数的影响进行了研究。年龄与所有 LR 指标呈负相关,而教育与大多数 LR 指标呈正相关。未发现性别差异。可以根据年龄和教育预测 LR 值,然后将其与观察到的 LR 值进行比较,并转换为经过人口统计学校正的分数。
通过比较基于回归预测方程计算出的观察到的和预测的 LR 分数,可以进行有助于临床决策和治疗计划的解释。HVLT-R 和 BVMT-R 的共同标准化也允许在个体患者中比较言语和视觉学习斜率分数。我们希望 LR 的正常数据能够增强其作为一种临床工具的效用,用于检查接受 HVLT-R 和/或 BVMT-R 测试的老年人的学习斜率。