几种退行性疾病中乙酰胆碱和尼古丁结合的减少。
Reductions in acetylcholine and nicotine binding in several degenerative diseases.
作者信息
Whitehouse P J, Martino A M, Marcus K A, Zweig R M, Singer H S, Price D L, Kellar K J
机构信息
Neuropathology Laboratory, Johns Hopkins University School of Medicine, Baltimore.
出版信息
Arch Neurol. 1988 Jul;45(7):722-4. doi: 10.1001/archneur.1988.00520310028012.
Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.
阿尔茨海默病、帕金森病和进行性核上性麻痹的共同特征是基底前脑胆碱能系统中的神经元丧失，以及皮质突触前胆碱能标志物（如胆碱乙酰转移酶）的相应减少。在本报告中，我们确定这些疾病中一种主要的皮质受体改变是使用氚化乙酰胆碱和左旋氚化尼古丁结合法测量的烟碱受体减少。
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