Whitehouse P J, Martino A M, Antuono P G, Lowenstein P R, Coyle J T, Price D L, Kellar K J
Brain Res. 1986 Apr 16;371(1):146-51. doi: 10.1016/0006-8993(86)90819-x.
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
在阿尔茨海默病（AD）中，大脑皮层存在突触前胆碱能标志物缺失的情况，但胆碱能受体变化的本质尚不清楚。在本研究中，[3H]乙酰胆碱和[3H]尼古丁被用于标记从AD患者及匹配对照组尸检获取的大脑皮质组织中的烟碱型胆碱能结合位点。研究发现AD中烟碱型受体存在持续且严重的缺失。
