Molecular Nutrition Branch, National Engineering Laboratory for Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Food Funct. 2021 Apr 21;12(8):3296-3306. doi: 10.1039/d0fo02240c. Epub 2021 Apr 12.
Cereal grains and oils contain various functional ingredients, such as amino acids, peptides, polyphenols, dietary fiber, linoleic acid, and natural pigments. Their biological activities are of great significance. Benefiting from its robust genetic function and simple cultivation, Caenorhabditis elegans, as one of the most important model organisms has been widely used to screen antiaging substances and investigate the underlying molecular mechanisms. In this paper, the recent advances in the use of C. elegans in antiaging research into active substances from cereals and oils will be assessed, and their potential signal transduction mechanisms will be systematically reviewed. This research aims to provide a theoretical reference for the use of active substances from cereals and oils to prevent and delay aging and aging-associated diseases.
谷物和油脂含有各种功能成分，如氨基酸、肽、多酚、膳食纤维、亚油酸和天然色素。它们的生物活性具有重要意义。得益于其强大的遗传功能和简单的栽培，秀丽隐杆线虫作为最重要的模式生物之一，已被广泛用于筛选抗衰老物质和研究潜在的分子机制。本文评估了利用秀丽隐杆线虫研究谷物和油脂中抗衰老活性物质的最新进展，并系统地综述了其潜在的信号转导机制。本研究旨在为利用谷物和油脂中的活性物质预防和延缓衰老及衰老相关疾病提供理论参考。
