Food Research Center-(FoRC-CEPID) and Department of Food Science and Experimental Nutrition, School of Pharmaceutical Science, University of São Paulo, São Paulo, SP, Brazil.
Food Funct. 2021 Apr 21;12(8):3680-3691. doi: 10.1039/d0fo03245j. Epub 2021 Apr 1.
Some polyphenols have been reported to modulate the expression of several genes related to lipid metabolism and insulin signaling, ameliorating metabolic disorders. We investigated the potential for the polyphenols of two varieties of grumixama, the purple fruit rich in anthocyanins and the yellow fruit, both also rich in ellagitannins, to attenuate obesity-associated metabolic disorders. Mice were fed a high fat and high sucrose diet, supplemented daily with yellow and purple extracts (200 mg per kg of body weight) for eight weeks. Purple grumixama supplementation was found to decrease body weight gain, improve insulin sensitivity and glucose-induced hyperinsulinemia, and reduce hepatic triglyceride accumulation. A decrease in intrahepatic lipids in mice treated with the purple grumixama extract was associated with lipid metabolism modulation by the PPAR signaling pathway. LPL, ApoE, and LDLr were found to be down-regulated, while Acox1 and ApoB were found to be upregulated. Some of these genes were also modulated by the yellow extract. In addition, both extracts decreased oGTT and plasma LPS. The results were associated with the presence of phenolic acids and urolithins. In conclusion, most likely the anthocyanins from the purple grumixama phenolic extract is responsible for reducing obesity and insulin resistance.
一些多酚已被报道可调节与脂代谢和胰岛素信号相关的几个基因的表达，从而改善代谢紊乱。我们研究了两种格木果（富含花色苷的紫色水果和富含鞣花单宁的黄色水果）多酚的潜力，以减轻与肥胖相关的代谢紊乱。用高脂肪和高蔗糖饮食喂养小鼠，并每天补充黄色和紫色提取物（每公斤体重 200 毫克）八周。发现紫色格木果补充剂可减少体重增加，改善胰岛素敏感性和葡萄糖诱导的高胰岛素血症，并减少肝内甘油三酯的积累。用紫色格木果提取物处理的小鼠肝内脂质减少与 PPAR 信号通路调节脂质代谢有关。发现 LPL、ApoE 和 LDLr 下调，而 Acox1 和 ApoB 上调。黄色提取物也调节了其中一些基因。此外，两种提取物都降低了 oGTT 和血浆 LPS。这些结果与存在的酚酸和尿石素有关。总之，很可能是紫色格木果多酚提取物中的花色苷可降低肥胖和胰岛素抵抗。
