School of Parmacy and Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
Department of Molecular Biophysics and Biochemistry, School of Medicine, Yale University, New Haven, Connecticut, USA.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2199168. doi: 10.1080/14756366.2023.2199168.
Flavonoids are ubiquitous compounds in nature and are found in many Chinese herbal medicines. Due to their biological activity, flavonoids show potential for decreasing insulin resistance (IR), thereby delaying the progression of diabetes and accompanying metabolic syndromes. This review focuses on the mechanisms of flavonoids decreasing IR: (1) the interaction between flavonoids and target proteins of the insulin signalling pathway; (2) bioactivities of flavonoids, such as anti-inflammatory, lipid-lowering and antioxidant. Meanwhile, we summarise the structural characteristics, structure activity relationships and biological activity of flavonoids, providing evidence for their potential in the treatment of IR. Here, we also analyse the potential and limitations of their therapeutic use.
类黄酮是自然界中普遍存在的化合物，存在于许多中草药中。由于其生物活性，类黄酮具有降低胰岛素抵抗（IR）的潜力，从而延缓糖尿病及其伴随的代谢综合征的进展。本综述重点介绍了类黄酮降低 IR 的机制：（1）类黄酮与胰岛素信号通路靶蛋白的相互作用；（2）类黄酮的生物活性，如抗炎、降脂和抗氧化作用。同时，我们总结了类黄酮的结构特征、构效关系和生物活性，为其在 IR 治疗中的应用提供了依据。在这里，我们还分析了它们治疗用途的潜力和局限性。
