Department of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil.
Arch Microbiol. 2021 Aug;203(6):3467-3472. doi: 10.1007/s00203-021-02281-y. Epub 2021 Apr 26.
Stomach pathologies develop in a complex interaction between the host's genetic background and H. pylori virulent genes. Thus, our study aimed to compare active chronic gastritis (ACG), and intestinal metaplasia (IM) with inactive chronic gastritis (ICG), according to interleukin polymorphisms of IL6-174 G/C, IL8-251 A/T, IL1β-511 C/T, and IL1RN VNTR taking into account patient gender and H. pylori genotypes. Interleukin polymorphisms were determined by RFLP-PCR and H. pylori genotype by PCR. IL6-174 GC and IL8-251 T allele showed a protective effect in women against ACG development and, conversely, IL8-251 polymorphism showed a risk for men. More virulent H. pylori strains were associated with the IL8-251 T allele and IL1β-511 T allele in the AGC, and the vacA m1 allele and cagE gene from H. pylori was associated with the IM. Analysis of the progression of gastric lesions must take into account host variability genetic associated with genes H. pylori due to the relation between the virulent H. pylori genes and more severe gastric lesions, besides the relevance to the gender to IL6-174 and IL8-251 polymorphisms.
胃病理学的发展是宿主遗传背景和 H. pylori 毒力基因之间复杂相互作用的结果。因此，我们的研究旨在比较活性慢性胃炎（ACG）和肠化生（IM）与非活性慢性胃炎（ICG），根据白细胞介素 6-174 G/C、白细胞介素 8-251 A/T、白细胞介素 1β-511 C/T 和白细胞介素 1RN VNTR 的多态性，同时考虑患者性别和 H. pylori 基因型。白细胞介素多态性通过 RFLP-PCR 确定，H. pylori 基因型通过 PCR 确定。白细胞介素 6-174 GC 和白细胞介素 8-251 T 等位基因对女性 ACG 发病有保护作用，而白细胞介素 8-251 多态性对男性有风险。更具毒力的 H. pylori 菌株与 AGC 中的白细胞介素 8-251 T 等位基因和白细胞介素 1β-511 T 等位基因相关，而 H. pylori 的 vacA m1 等位基因和 cagE 基因与 IM 相关。分析胃病变的进展必须考虑与宿主相关的基因多态性，因为与毒力 H. pylori 基因的关系，除了与性别相关的白细胞介素 6-174 和白细胞介素 8-251 多态性外，还与更严重的胃病变有关。
