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人类中东呼吸综合征冠状病毒抗体反应的持久性，沙特阿拉伯。

Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia.

出版信息

Emerg Infect Dis. 2021 May;27(5):1472-6. doi: 10.3201/eid2705.204056.

DOI:10.3201/eid2705.204056
PMID:33900908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8084512/
Abstract

Understanding the immune response to Middle East respiratory syndrome coronavirus (MERS-CoV) is crucial for disease prevention and vaccine development. We studied the antibody responses in 48 human MERS-CoV infection survivors who had variable disease severity in Saudi Arabia. MERS-CoV-specific neutralizing antibodies were detected for 6 years postinfection.

摘要

了解中东呼吸综合征冠状病毒（MERS-CoV）的免疫反应对于疾病预防和疫苗开发至关重要。我们研究了 48 名在沙特阿拉伯感染 MERS-CoV 后病情轻重不一的幸存者的抗体反应。在感染后 6 年内检测到了 MERS-CoV 特异性中和抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/8084512/be988f412fed/20-4056-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/8084512/be988f412fed/20-4056-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/8084512/be988f412fed/20-4056-F.jpg

相似文献

[1]
Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia.

Emerg Infect Dis. 2021-5

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia.

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[9]
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[10]
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引用本文的文献

[1]
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans.

Cell Rep. 2024-8-27

[2]
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans.

bioRxiv. 2024-4-2

[3]
Symptomatic MERS-CoV infection reduces the risk of future COVID-19 disease; a retrospective cohort study.

BMC Infect Dis. 2023-11-3

[4]
SARS-CoV-2 spike-specific T cells exhibit unique responses in infected and vaccinated individuals.

Signal Transduct Target Ther. 2023-10-6

[5]
A mixed-method analysis to identify the current focus, trends, and gaps in health science research in Saudi Arabia.

Front Public Health. 2022

[6]
Reinfection and reactivation of SARS-CoV-2.

Future Virol. 2022-9

[7]
Immunogenicity of High-Dose MVA-Based MERS Vaccine Candidate in Mice and Camels.

Vaccines (Basel). 2022-8-17

[8]
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection.

Cell Rep Med. 2022-2-15

[9]
Advances in mRNA and other vaccines against MERS-CoV.

Transl Res. 2022-4

[10]
Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi Arabia.

Front Immunol. 2021

本文引用的文献

[1]
Lessons for COVID-19 Immunity from Other Coronavirus Infections.

Immunity. 2020-7-14

[2]
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J Clin Invest. 2020-10-1

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N Engl J Med. 2020-2-20

[4]
High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia.

mBio. 2018-10-30

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Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses.

Sci Immunol. 2017-8-4

[6]
MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015.

Emerg Infect Dis. 2017-7

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Emerg Microbes Infect. 2017-1-4

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Emerg Infect Dis. 2016-10

[9]
Antibody Response and Disease Severity in Healthcare Worker MERS Survivors.

Emerg Infect Dis. 2016-6

[10]
A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates.

Sci Transl Med. 2015-8-19

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