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本文引用的文献

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Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.韩国人类中东呼吸综合征冠状病毒感染血清学反应的动力学
Emerg Infect Dis. 2015 Dec;21(12):2186-9. doi: 10.3201/eid2112.151421.
2
Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection.37例中东呼吸综合征冠状病毒感染患者的病毒脱落与抗体反应
Clin Infect Dis. 2016 Feb 15;62(4):477-483. doi: 10.1093/cid/civ951. Epub 2015 Nov 12.
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Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.沙特阿拉伯中东呼吸综合征冠状病毒抗体的存在情况：一项全国性横断面血清学研究。
Lancet Infect Dis. 2015 May;15(5):559-64. doi: 10.1016/S1473-3099(15)70090-3. Epub 2015 Apr 8.
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Transmission of MERS-coronavirus in household contacts.家庭接触者中东呼吸综合征冠状病毒的传播。
N Engl J Med. 2014 Aug 28;371(9):828-35. doi: 10.1056/NEJMoa1405858.
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Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection.病毒特异性记忆 CD8 T 细胞为严重急性呼吸综合征冠状病毒致死性感染提供了实质性保护。
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Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description.医院内中东呼吸综合征冠状病毒暴发：血清学、流行病学及临床描述
Clin Infect Dis. 2014 Nov 1;59(9):1225-33. doi: 10.1093/cid/ciu359. Epub 2014 May 14.
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Serological assays for emerging coronaviruses: challenges and pitfalls.新型冠状病毒的血清学检测：挑战与陷阱
Virus Res. 2014 Dec 19;194:175-83. doi: 10.1016/j.virusres.2014.03.018. Epub 2014 Mar 23.
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Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012.2012 年秋季沙特阿拉伯吉达和麦加的献血者和屠宰场工人血液中抗中东呼吸综合征抗体的调查。
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Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012.2012 年 10 月至 11 月德国医院诊治的人类新型冠状病毒感染病例的接触者调查。
Euro Surveill. 2013 Feb 21;18(8):20406.
10
Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections.新型人类冠状病毒（hCoV-EMC）感染的实验室确诊检测方法。
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医护人员中东呼吸综合征幸存者的抗体反应与疾病严重程度

Antibody Response and Disease Severity in Healthcare Worker MERS Survivors.

作者信息

Alshukairi Abeer N, Khalid Imran, Ahmed Waleed A, Dada Ashraf M, Bayumi Daniyah T, Malic Laut S, Althawadi Sahar, Ignacio Kim, Alsalmi Hanadi S, Al-Abdely Hail M, Wali Ghassan Y, Qushmaq Ismael A, Alraddadi Basem M, Perlman Stanley

出版信息

Emerg Infect Dis. 2016 Jun;22(6):1113-5. doi: 10.3201/eid2206.160010.

DOI:10.3201/eid2206.160010
PMID:27192543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4880093/
Abstract

We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease.

摘要

我们通过连续酶联免疫吸附测定（ELISA）和间接免疫荧光测定试验，对沙特阿拉伯吉达9名从中东呼吸综合征中康复的医护人员的抗体反应进行了研究。在经历过严重肺炎的患者中，感染后18个月以上仍可检测到抗体。病情较轻的患者抗体持续时间变化更大。