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酶动力学稳态速率方程的计算机推导

The computerized derivation of steady-state rate equations for enzyme kinetics.

作者信息

Herries D G

出版信息

Biochem J. 1984 Oct 15;223(2):551-3. doi: 10.1042/bj2230551.

DOI:10.1042/bj2230551
PMID:6497862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144331/
Abstract

A FORTRAN 77 program is described for the derivation of steady-state rate equations for enzyme kinetics. Input is very simple and consists of the two enzyme forms and the two rate constants for each step in the mechanism. The program may be run interactively or off-line. The results are produced after collecting together the algebraic coefficients of like concentration terms, taking account of sign. A fully interactive BASIC version running on a BBC Microcomputer is also available. Details of the programs have been deposited as Supplementary Publication SUP 50126 (45 pages) with the British Library Lending Division, Boston Spa, Wetherby, West Yorkshire LS23 7BQ, U.K., from whom copies may be obtained as indicated in Biochem. J. (1984) 217, 5.

摘要

本文描述了一个用于推导酶动力学稳态速率方程的FORTRAN 77程序。输入非常简单，包括两种酶形式以及反应机制中每一步的两个速率常数。该程序可以交互式运行，也可以离线运行。在考虑符号的情况下，将同类浓度项的代数系数合并后得出结果。还有一个在BBC微型计算机上运行的完全交互式BASIC版本。这些程序的详细内容已作为补充出版物SUP 50126（45页）存放在英国西约克郡韦瑟比波士顿温泉市英国国家图书馆出借部，其地址为LS23 7BQ，可按《生物化学杂志》（1984年）第217卷第5期所示方式从该处获取副本。

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本文引用的文献

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The simulation and analysis by digital computer of biochemical systems in terms of kinetic models. IV. Automatic derivation of enzymic rate laws.基于动力学模型，利用数字计算机对生化系统进行模拟与分析。IV. 酶促反应速率方程的自动推导。
J Theor Biol. 1968 Sep;20(3):297-313. doi: 10.1016/0022-5193(68)90130-6.
2
A computer program for writing the steady-state rate equation for a multisubstrate enzymic reaction.一个用于编写多底物酶促反应稳态速率方程的计算机程序。
Can J Biochem. 1969 Oct;47(10):941-4. doi: 10.1139/o69-147.
3
Enzyme kinetics. Systematic generation of valid King-Altman patterns.酶动力学。有效金-奥特曼模式的系统生成。
Biophys J. 1972 Mar;12(3):248-56. doi: 10.1016/S0006-3495(72)86084-3.
4
Some kinetic properties of human-milk galactosyl transferase.人乳半乳糖基转移酶的一些动力学特性。
Eur J Biochem. 1974 May 15;44(2):537-60. doi: 10.1111/j.1432-1033.1974.tb03513.x.
5
An automatic method for deriving steady-state rate equations.一种推导稳态速率方程的自动方法。
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6
Bovine galactosyl transferase. Substrate.managanese complexes and the role of manganese ions in the mechanism.牛半乳糖基转移酶。底物、锰复合物以及锰离子在该机制中的作用。
Eur J Biochem. 1978 Feb 1;83(1):179-88. doi: 10.1111/j.1432-1033.1978.tb12082.x.

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