Barth T, Klingberg F
Paul Flechsig Institute for Brain Research, Department of Neurophysiology, Karl Marx University, Leipzig, GDR.
Biomed Biochim Acta. 1988;47(1):51-6.
Spontaneous and active avoidance behaviour was compared pre- and postoperatively on 11 six month old male hooded rats of the Long-Evans strain. Seven of them with small bilateral symmetric lesions only in the ventromedial part of substantia nigra pars reticulata (SNR) were characterized by a strong decrease of exploratory parameters except rearings, without differences of ambulatory activity in the open field (OF) test. The SNR group showed a significant retention loss, increased reaction times and run durations in three variants of preoperatively consolidated Y-maze performance and weakened brightness discrimination. They were unable to relearn the tasks and to reduce errors to the preoperative level which was zero. Postoperative acquisition of a new active avoidance stereotype in the jump test box was impossible. They ignored the hanging rod in this box and did not find the escape possibility. Prevailing flexor tonus of trunk and forelegs after SNR lesions was no sufficient reason for these changes, because inborn and automated programs were far less concerned than learnt or operative programs and the accuracy of goal-directed behaviour.
对11只6个月大的雄性长爪沙鼠（Long-Evans品系）进行手术前后自发和主动回避行为的比较。其中7只仅在黑质网状部腹内侧有小的双侧对称损伤，其特点是除直立行为外，探索参数显著降低，在旷场（OF）试验中自主活动无差异。黑质网状部组在术前巩固的Y迷宫任务的三个变体中表现出显著的记忆丧失、反应时间延长和奔跑持续时间增加，以及亮度辨别能力减弱。它们无法重新学习任务并将错误减少到术前的零水平。术后在跳跃试验箱中习得新的主动回避模式是不可能的。它们忽视了试验箱中的悬挂杆，没有找到逃脱的可能性。黑质网状部损伤后躯干和前肢普遍出现屈肌紧张，这并非这些变化的充分原因，因为先天和自动程序与学习或操作程序以及目标导向行为的准确性相比，受影响要小得多。
