Hammer K H, Klingberg F
Paul Flechsig Institute for Brain Research, Department of Neurophysiology, Karl Marx University, Leipzig, DDR.
Biomed Biochim Acta. 1990;49(6):489-97.
Active avoidance learning, retention and relearning were investigated before and after lesions of the interpeduncular nucleus (IP) of rat in a Y-maze and a jump test box. Preoperatively learnt active avoidance was abolished after the lesions and rats were not able to relearn it. Unconditioned escape responses remained unchanged in the Y-maze. Postoperative avoidance learning was impossible. Brightness discrimination in a goal alternation paradigm was learned or relearned, respectively, after IP lesions. The IP rats were hypoactive and showed diminished exploratory activity but had unchanged escape speed. The IP is evidently enclosed in a network controlling avoidance behaviour.
在Y迷宫和跳跃测试箱中，研究了大鼠脚间核（IP）损伤前后的主动回避学习、记忆保持和重新学习情况。损伤后，术前习得的主动回避行为消失，大鼠无法重新学习。在Y迷宫中，非条件逃避反应保持不变。术后无法进行回避学习。IP损伤后，分别进行了目标交替范式中的亮度辨别学习或重新学习。IP大鼠活动不足，探索活动减少，但逃避速度不变。显然，脚间核被包含在一个控制回避行为的网络中。
