Mager P, Mager R, Klingberg F
Biomed Biochim Acta. 1986;45(4):477-83.
Two groups of each 6 male hooded rats with bilateral symmetrical lesions in the anterior dorsolateral tegmentum including parts of the anterior and posterior pretectal nuclei and two sham-operated control groups were compared in different avoidance paradigms. The acquisition of conditioned avoidance responses (CAR) in a Y-maze was significantly retarded in lesioned rats and remained definitely on a lower performance level. Their reaction times (RTs) were significantly prolonged. Brightness discrimination was severely impaired. They had evidently troubles to correct their erroneous runs. After preoperative training lesioned rats had no retention deficit in the Y-maze performance, neither different RTs nor changes of running speed, but a deficit in brightness discrimination. Postoperative acquisition of CAR in a jump test was impossible. Retention of preoperatively learnt CAR in the jump test was zero, relearning was impossible reaching not more than 40% CAR performance after 8 sessions. The behavioural syndrome was different from other tegmental lesion types. Impaired brightness discrimination and vertical visual orientation are main symptoms of the more complex disturbance of goal-directed behaviour.
将两组各6只在前背外侧被盖区有双侧对称性损伤（包括部分前顶盖前核和后顶盖前核）的雄性带帽大鼠，与两个假手术对照组，在不同的回避范式中进行比较。损伤大鼠在Y迷宫中条件性回避反应（CAR）的习得明显延迟，且表现水平一直明显较低。它们的反应时间（RTs）显著延长。亮度辨别能力严重受损。它们在纠正错误奔跑方面明显有困难。术前训练后，损伤大鼠在Y迷宫表现中没有记忆缺陷，反应时间和奔跑速度也没有变化，但亮度辨别存在缺陷。在跳跃试验中，损伤大鼠术后无法习得CAR。术前习得的CAR在跳跃试验中的记忆保持率为零，重新学习也不可能，8次训练后CAR表现不超过40%。行为综合征与其他被盖区损伤类型不同。亮度辨别受损和垂直视觉定向是目标导向行为更复杂障碍的主要症状。
