Yadav Upendra, Kumar Pradeep, Rai Vandana
Human Molecular Genetics Laboratory, Department of Biotechnology, VBS Purvanchal University, Jaunpur, UP, India.
Human Molecular Genetics Laboratory, Department of Biotechnology, VBS Purvanchal University, Jaunpur, UP, India.
Infect Genet Evol. 2021 Aug;92:104871. doi: 10.1016/j.meegid.2021.104871. Epub 2021 Apr 24.
Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.
Different databases were screened up to November 2020 with the keywords "Vitamin D receptor", "VDR", and "FokI", along with "Tuberculosis" and "TB" to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.
No statistically significant association was observed in the allele contrast model (OR = 1.11, 95%CI = 0.99-1.24, p = 0.05, I = 73.46%), in the dominant model (OR = 1.11, 95%CI = 0.96-1.28, p = 0.14, I = 71.39%), and in the co-dominant model (OR = 1.05, 95%CI = 0.92-1.21, p = 0.41, I = 65.97%). However, a significant association was found in the homozygote model (OR = 1.32, 95%CI = 1.03-1.69, p = 0.02, I = 67.02%) and in the recessive model (OR = 1.26, 95%CI = 1.03-1.54, p = 0.02, I = 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (OR = 1.57, 95%CI = 1.12-2.21, p = 0.008, I = 70.37%) and in the recessive model (OR = 1.43, 95%CI = 1.08-1.89, p = 0.01, I = 63.13%).
In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.
结核病是全球十大死因之一。据报道，维生素D缺乏与结核病易感性增加有关。此前发表了各种报告来检验维生素D受体基因的FokI多态性与结核病风险的关联。但它们的结果不一致，因此，我们进行了一项荟萃分析以了解两者的确切关系。
截至2020年11月，使用关键词“维生素D受体”、“VDR”、“FokI”以及“结核病”和“TB”对不同数据库进行筛选，以找到合适的文章。所有统计分析均通过开放元分析程序进行，所有p值均为双侧，显著性水平为0.05。
在等位基因对比模型（OR = 1.11，95%CI = 0.99 - 1.24，p = 0.05，I = 73.46%）、显性模型（OR = 1.11，95%CI = 0.96 - 1.28，p = 0.14，I = 71.39%）和共显性模型（OR = 1.05，95%CI = 0.92 - 1.21，p = 0.41，I = 65.97%）中未观察到统计学上的显著关联。然而，在纯合子模型（OR = 1.32，95%CI = 1.03 - 1.69，p = 0.02，I = 67.02%）和隐性模型（OR = 1.26，95%CI = 1.03 - 1.54，p = 0.02，I = 58.01%）中发现了显著关联。基于种族进行了进一步分析。在亚洲人群中，在纯合子模型（OR = 1.57，95%CI = 1.12 - 2.21，p = 0.008，I = 70.37%）和隐性模型（OR = 1.43，95%CI = 1.08 - 1.89，p = 0.01，I = 63.13%）中发现了显著关联。
总之，在总体分析和亚洲人群中发现FokI与结核病易感性存在显著关联。
