维生素D受体（VDR）基因的FokI多态性与结核病易感性：一项荟萃分析的证据

FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: Evidence through a meta-analysis.

作者信息

Yadav Upendra, Kumar Pradeep, Rai Vandana

机构信息

Human Molecular Genetics Laboratory, Department of Biotechnology, VBS Purvanchal University, Jaunpur, UP, India.

出版信息

Infect Genet Evol. 2021 Aug;92:104871. doi: 10.1016/j.meegid.2021.104871. Epub 2021 Apr 24.

DOI:10.1016/j.meegid.2021.104871

PMID:33901685

Abstract

BACKGROUND

Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.

METHODS

Different databases were screened up to November 2020 with the keywords "Vitamin D receptor", "VDR", and "FokI", along with "Tuberculosis" and "TB" to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.

RESULTS

No statistically significant association was observed in the allele contrast model (OR = 1.11, 95%CI = 0.99-1.24, p = 0.05, I = 73.46%), in the dominant model (OR = 1.11, 95%CI = 0.96-1.28, p = 0.14, I = 71.39%), and in the co-dominant model (OR = 1.05, 95%CI = 0.92-1.21, p = 0.41, I = 65.97%). However, a significant association was found in the homozygote model (OR = 1.32, 95%CI = 1.03-1.69, p = 0.02, I = 67.02%) and in the recessive model (OR = 1.26, 95%CI = 1.03-1.54, p = 0.02, I = 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (OR = 1.57, 95%CI = 1.12-2.21, p = 0.008, I = 70.37%) and in the recessive model (OR = 1.43, 95%CI = 1.08-1.89, p = 0.01, I = 63.13%).

CONCLUSION

In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.

摘要

背景

结核病是全球十大死因之一。据报道，维生素D缺乏与结核病易感性增加有关。此前发表了各种报告来检验维生素D受体基因的FokI多态性与结核病风险的关联。但它们的结果不一致，因此，我们进行了一项荟萃分析以了解两者的确切关系。

方法

截至2020年11月，使用关键词“维生素D受体”、“VDR”、“FokI”以及“结核病”和“TB”对不同数据库进行筛选，以找到合适的文章。所有统计分析均通过开放元分析程序进行，所有p值均为双侧，显著性水平为0.05。

结果

在等位基因对比模型（OR = 1.11，95%CI = 0.99 - 1.24，p = 0.05，I = 73.46%）、显性模型（OR = 1.11，95%CI = 0.96 - 1.28，p = 0.14，I = 71.39%）和共显性模型（OR = 1.05，95%CI = 0.92 - 1.21，p = 0.41，I = 65.97%）中未观察到统计学上的显著关联。然而，在纯合子模型（OR = 1.32，95%CI = 1.03 - 1.69，p = 0.02，I = 67.02%）和隐性模型（OR = 1.26，95%CI = 1.03 - 1.54，p = 0.02，I = 58.01%）中发现了显著关联。基于种族进行了进一步分析。在亚洲人群中，在纯合子模型（OR = 1.57，95%CI = 1.12 - 2.21，p = 0.008，I = 70.37%）和隐性模型（OR = 1.43，95%CI = 1.08 - 1.89，p = 0.01，I = 63.13%）中发现了显著关联。