Department of Orthopedics & Spine Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Rheumatology (Oxford). 2021 Feb 1;60(2):538-548. doi: 10.1093/rheumatology/keaa644.
To investigate the association of vitamin D receptor (VDR) gene polymorphisms with OA susceptibility.
Meta-analyses were performed using allelic contrast, contrast of homozygotes, and recessive and dominant models to clarify the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms. Odds ratio (OR) and the corresponding 95% CI were obtained, and subgroup analyses were performed based on the ethnicity and OA sites.
A total of 18 studies with 2983 OA patients and 4177 controls were included in this meta-analysis. There were statistically significant associations in the spine between OA susceptibility and the VDR BsmI (B vs b: OR = 1.25, 95% CI: 1.03, 1.53, P = 0.026; BB vs bb: OR = 1.56, 95% CI: 1.02, 2.37, P = 0.038) and TaqI (T vs t: OR = 0.73, 95% CI: 0.54, 0.99, P = 0.044; TT vs Tt + tt: OR = 0.63, 95% CI: 0.42, 0.95, P = 0.028) polymorphisms, but not for the other polymorphisms. A statistically significant association was found between the VDR FokI polymorphism and OA susceptibility in the knee in the recessive model contrast (FF vs Ff + ff: OR = 0.63, 95% CI: 0.42, 0.95, P = 0.028), but this result was only pooled from one study. However, no significant associations were found between the VDR ApaI polymorphism and OA. Besides, ethnic stratification also indicated that there was no significant association between VDR gene polymorphism and OA in Caucasians or Asians.
Our meta-analysis suggests that the VDR BsmI and TaqI polymorphisms are associated with OA susceptibility in the spine. However, the VDR ApaI polymorphism is not a significant genetic risk factor for OA.
探讨维生素 D 受体（VDR）基因多态性与骨关节炎（OA）易感性的关系。
采用等位基因对比、纯合子对比、隐性和显性模型进行荟萃分析，以明确 VDR ApaI、BsmI、TaqI 和 FokI 多态性与 OA 之间的关系。计算比值比（OR）和相应的 95%置信区间，并根据种族和 OA 部位进行亚组分析。
本荟萃分析共纳入 18 项研究，包括 2983 例 OA 患者和 4177 例对照。VDR BsmI 多态性（B vs b：OR=1.25，95%CI：1.03，1.53，P=0.026；BB vs bb：OR=1.56，95%CI：1.02，2.37，P=0.038）和 TaqI 多态性（T vs t：OR=0.73，95%CI：0.54，0.99，P=0.044；TT vs Tt+tt：OR=0.63，95%CI：0.42，0.95，P=0.028）与脊柱 OA 易感性相关，而其他多态性与 OA 易感性无关。VDR FokI 多态性在隐性模型对比中与膝关节 OA 易感性相关（FF vs Ff+ff：OR=0.63，95%CI：0.42，0.95，P=0.028），但该结果仅来自一项研究。此外，VDR ApaI 多态性与 OA 无关。此外，种族分层也表明，VDR 基因多态性与白种人和亚洲人 OA 之间没有显著关联。
本荟萃分析表明，VDR BsmI 和 TaqI 多态性与脊柱 OA 易感性相关，而 VDR ApaI 多态性不是 OA 的显著遗传危险因素。
