Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
Ophthalmol Retina. 2022 Jan;6(1):43-48. doi: 10.1016/j.oret.2021.04.012. Epub 2021 Apr 24.
To characterize the clinical features of occlusive retinal vasculitis (ORV).
Retrospective case series.
Forty-two patients with ORV.
A retrospective chart review identified all patients with ORV seen at the University of Colorado uveitis service between January 2013 and April 2020. All included patients demonstrated noninfectious uveitis and evidence of vascular occlusion in the presence of retinal vascular inflammation on widefield fluorescein angiography.
Demographic data, visual acuity, clinical findings, and fluorescein angiography findings.
We identified 73 eyes from 42 patients (15 men, 27 women) with ORV. Thirty-one of 42 patients had bilateral disease. Most eyes (54/73) showed mixed arteriolar and venous vasculitis compared with primarily arteriolar (6/73) or venous (15/73) vasculitis. Thirteen of 42 patients had an underlying systemic condition, most commonly granulomatosis with polyangiitis; however, bilaterality was not associated with a systemic condition. Retinal nonperfusion was present equally in zone 2 (28/73) and zone 3 (28/73) compared with zone 1 (16/73). Retinal or iris neovascularization was present in 25 of 73 eyes. Eighteen of 42 patients required more than 1 immunosuppressive medication (average, 1.33) to prevent progressive vascular occlusive disease.
Occlusive retinal vasculitis is a heterogeneous entity with significant risk of visual impairment. Systemic disease was more prevalent in this specific cohort compared with cohorts from prior studies of retinal vasculitis.
描述闭塞性视网膜血管炎（ORV）的临床特征。
回顾性病例系列。
42 例 ORV 患者。
回顾性图表审查确定了 2013 年 1 月至 2020 年 4 月在科罗拉多大学葡萄膜炎服务中心就诊的所有 ORV 患者。所有纳入的患者均表现为非感染性葡萄膜炎，并在存在视网膜血管炎症的情况下，眼底荧光血管造影显示血管阻塞。
人口统计学数据、视力、临床发现和荧光血管造影发现。
我们从 42 例患者（15 例男性，27 例女性）中发现了 73 只眼患有 ORV。42 例患者中有 31 例双眼受累。与主要表现为动脉炎（6/73）或静脉炎（15/73）相比，73 只眼中的 54 只（54/73）表现为混合性动静脉血管炎。42 例患者中有 13 例存在潜在的系统性疾病，最常见的是肉芽肿性多血管炎；然而，双眼受累与系统性疾病无关。视网膜无灌注在 2 区（28/73）和 3 区（28/73）的发生率与 1 区（16/73）相同。73 只眼中有 25 只存在视网膜或虹膜新生血管。42 例患者中有 18 例需要使用超过 1 种免疫抑制药物（平均 1.33 种）来预防进行性血管闭塞性疾病。
闭塞性视网膜血管炎是一种异质性疾病，存在显著的视力损害风险。与之前的视网膜血管炎研究队列相比，该特定队列中系统性疾病更为普遍。
