Institut Curie, PSL Research University, INSERM, U932, 26 Rue d'Ulm, 75005, Paris, France; Université Paris Descartes, Paris, France.
Institut Curie, PSL Research University, INSERM, U932, 26 Rue d'Ulm, 75005, Paris, France.
Mol Immunol. 2021 Jul;135:165-169. doi: 10.1016/j.molimm.2021.04.012. Epub 2021 Apr 23.
Antigen presentation is a key feature of classical dendritic cells (cDCs). Numerous studies have also reported in mouse that, upon inflammation, monocytes enter tissues and differentiate into monocyte-derived DCs (mo-DC) that have the ability to present antigens to T cells. However, a population of inflammatory cDCs sharing phenotypic features with mo-DC has been recently described, challenging the existence of in vivo-generated mo-DC. Here we review studies describing mouse mo-DC in the light of these findings, and evaluate the in vivo evidence for monocyte-derived antigen-presenting cells. We examine the strategies used to demonstrate the monocytic origin of these cells. Finally, we propose that mo-DC play a complementary role to cDCs, by presenting antigens to effector T cells locally in tissues.
抗原呈递是经典树突状细胞（cDCs）的一个关键特征。许多研究还在小鼠中报告说，在炎症时，单核细胞进入组织并分化为具有向 T 细胞呈递抗原能力的单核细胞衍生的 DC（mo-DC）。然而，最近描述了一群具有与 mo-DC 表型特征相似的炎性 cDC，这对体内生成的 mo-DC 的存在提出了挑战。在这里，我们根据这些发现来回顾描述小鼠 mo-DC 的研究，并评估体内关于单核细胞来源的抗原呈递细胞的证据。我们研究了用于证明这些细胞的单核细胞起源的策略。最后，我们提出 mo-DC 通过在组织中局部向效应 T 细胞呈递抗原，发挥与 cDCs 互补的作用。
