Mildner Alexander, Kim Ki-Wook, Yona Simon
MediCity Research Laboratory, University of Turku, Turku, Finland.
InFLAMES Research Flagship, University of Turku, 20014 Turku, Finland.
Discov Immunol. 2024 Aug 30;3(1):kyae014. doi: 10.1093/discim/kyae014. eCollection 2024.
Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.
单核细胞是固有免疫系统的关键组成部分。它们在骨髓中经历复杂的发育过程，从而在循环系统中产生多种单核细胞亚群。在健康的体内平衡状态下，单核细胞持续释放到血液中， destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. 然而，在病理条件下，单核细胞会呈现出各种表型以解决炎症并恢复到健康的生理状态。本综述探讨了单核细胞所执行的细微发育途径和功能作用，揭示了它们在生理和病理环境中的重要性。
