Dotta Enrico, Maciola Agnieszka Katarzyna, Baccega Tania, Pasqual Giulia
Laboratory of Synthetic Immunology, Oncology and Immunology Section, Department of Surgery Oncology and Gastroenterology, University of Padua, Italy.
Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
FEBS Lett. 2025 Jul;599(14):2048-2059. doi: 10.1002/1873-3468.14982. Epub 2024 Jul 12.
Dendritic cells (DCs) play a central role in initiating and shaping the adaptive immune response, thanks to their ability to uptake antigens and present them to T cells. Once in the lymph node (LN), DCs can spread the antigen to other DCs, expanding the pool of cells capable of activating specific T-cell clones. Additionally, DCs can modulate the dynamics of other immune cells, by increasing naïve T-cell dwell time, thereby facilitating the scanning for cognate antigens, and by selectively recruiting other leukocytes. Here we discuss the role of DCs in orchestrating antigen and leukocyte trafficking within the LN, together with the implications of this trafficking on T-cell activation and commitment to effector function.
树突状细胞（DCs）在启动和塑造适应性免疫反应中发挥核心作用，这得益于它们摄取抗原并将其呈递给T细胞的能力。一旦进入淋巴结（LN），DCs可将抗原传播给其他DCs，从而扩大能够激活特定T细胞克隆的细胞库。此外，DCs可通过延长初始T细胞停留时间来调节其他免疫细胞的动态变化，从而促进对同源抗原的扫描，并通过选择性募集其他白细胞来实现这一点。在这里，我们讨论DCs在协调LN内抗原和白细胞运输中的作用，以及这种运输对T细胞激活和效应功能形成的影响。
