Zhu Di, Zhen Qingfang, Xin Jianjiao, Ma Huiyuan, Pang Haijun, Tan Lichao, Wang Xinming
School of Materials Science and Engineering, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin, 150040, PR China; College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, PR China.
School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, 150040, PR China.
J Colloid Interface Sci. 2021 Sep 15;598:181-192. doi: 10.1016/j.jcis.2021.04.048. Epub 2021 Apr 20.
An innovative electrochemical nanocomposite for the detection of guanosine (Gua) was proposed by in situ encapsulation of nickel-iron bimetallic selenides confined into honeycomb-like nitrogen doped porous carbon nanosheets, denoted as (Ni,Fe)Se/N-PCNs. The porous carbon nanosheets were prepared by utilizing nickel-iron layered double hydroxide (Ni-Fe LDH) as the substrate and zeolitic imidazolate frameworks (ZIF-67) nanocrystals as the sacrificial templates via hydrothermal synthesis, followed by a process of acid etching and pyrolysis selenylation. Interestingly, the nickel-ferric bimetallic selenides material (Ni,Fe)Se, is rarely fabricated successfully using selenylation treatment, which is a highly conductive and robust support to promote the electron transport. Meanwhile, the obtained (Ni,Fe)Se/N-PCNs have the favorable architectural features of both unique three-dimensional (3D) porous structural and hierarchical connectivity, which are expected to provide more active sites for electrochemical reactions and ease of electron, ion, and biomolecule penetration. Benefiting from the inherent virtues of its composition, together with unique structural advantages, the (Ni,Fe)Se/N-PCNs possess ideal sensing properties for guanosine detection with a low detection limit of 1.20 × 10 M, a wide linear range of 5.30 × 10 ~ 2.27 × 10 M and a good stability. Superb selectivity for potential interfering species and superb recoveries in serum suggests its feasibility for practical applications.
通过将镍铁双金属硒化物原位封装在蜂窝状氮掺杂多孔碳纳米片中，制备了一种用于检测鸟苷（Gua）的创新型电化学纳米复合材料，记为（Ni,Fe）Se/N-PCNs。多孔碳纳米片的制备方法是：以镍铁层状双氢氧化物（Ni-Fe LDH）为基底，以沸石咪唑酯骨架（ZIF-67）纳米晶体为牺牲模板，通过水热合成法制备，随后经过酸蚀刻和热解硒化过程。有趣的是，镍铁双金属硒化物材料（Ni,Fe）Se很少能通过硒化处理成功制备，它是一种高导电性且坚固的载体，有助于促进电子传输。同时，所制备的（Ni,Fe）Se/N-PCNs具有独特的三维（3D）多孔结构和分级连通性等良好的结构特征，有望为电化学反应提供更多活性位点，并便于电子、离子和生物分子渗透。得益于其组成的固有优点以及独特的结构优势，（Ni,Fe）Se/N-PCNs对鸟苷检测具有理想的传感性能，检测限低至1.20×10⁻⁸ M，线性范围宽达5.30×10⁻⁸~2.27×10⁻⁵ M，且具有良好的稳定性。对潜在干扰物质具有出色的选择性以及在血清中的出色回收率表明其在实际应用中的可行性。
