Department of Pediatrics, Konya Education and Research Hospital, University of Health Sciences, Konya, Turkey.
Department of Pediatric Radiology, Konya Education and Research Hospital, University of Health Sciences, Konya, Turkey.
Pediatr Pulmonol. 2021 Jul;56(7):1985-1991. doi: 10.1002/ppul.25426. Epub 2021 Apr 26.
This study aimed to compare chest computed tomography (CT) findings with reverse-transcription polymerase chain reaction (RT-PCR) test results in children with probable or definitive diagnosis of coronavirus disease 2019 (COVID-19).
In this retrospective archive study, pediatric patients who were followed up in the hospital with a possible or definitive diagnosis of COVID-19 and who had chest CT at presentation were included. CT scan images of the patients were reinterpreted by a pediatric radiologist and compared with their RT-PCR test results.
Of the total of 89 patients, 33 had negative and 56 had positive RT-PCR tests. The presence of pulmonary lesions and consolidation was statistically significantly higher in the RT-PCR negative group than in the RT-PCR positive group (p = 0.037 and 0.001, respectively). Lobe involvement of 0%-25% was higher in the RT-PCR positive group (p = 0.001), and lobe involvements of 25%-50% and 50%-75% were significantly higher in the RT-PCR negative group (p = 0.001 and 0.005, respectively). Central and perihilar involvement was found to be statistically significant in the RT-PCR negative group (p = 0.008 and 0.005, respectively).
Chest CT findings may provide some clues in predicting RT-PCR positivity in children with a probable diagnosis of COVID-19. Lobe involvement percentage of up to 25% is a finding in favor of patients with positive RT-PCR test, whereas 25%-75% lobe involvement, central and perihilar involvement, and consolidation can be interpreted in favor of patients with negative RT-PCR test.
本研究旨在比较疑似或明确诊断为 2019 年冠状病毒病（COVID-19）的儿童的胸部计算机断层扫描（CT）结果与逆转录聚合酶链反应（RT-PCR）检测结果。
在这项回顾性存档研究中，纳入了在医院接受疑似或明确 COVID-19 诊断并在就诊时进行胸部 CT 检查的儿科患者。由一名儿科放射科医生重新解读患者的 CT 扫描图像，并将其与 RT-PCR 检测结果进行比较。
在总共 89 名患者中，33 名 RT-PCR 检测结果为阴性，56 名 RT-PCR 检测结果为阳性。在 RT-PCR 阴性组中，肺部病变和实变的存在显著高于 RT-PCR 阳性组（p=0.037 和 0.001）。在 RT-PCR 阳性组中，累及 0%-25%的肺叶更为常见（p=0.001），而在 RT-PCR 阴性组中，累及 25%-50%和 50%-75%的肺叶更为常见（p=0.001 和 0.005）。在 RT-PCR 阴性组中，中央和肺门周围受累具有统计学意义（p=0.008 和 0.005）。
在疑似 COVID-19 的儿童中，胸部 CT 表现可能有助于预测 RT-PCR 阳性结果。累及肺叶比例达 25%以下提示 RT-PCR 检测结果阳性，而累及肺叶比例达 25%-75%、中央和肺门周围受累以及实变则提示 RT-PCR 检测结果阴性。
