Yamamoto Kei, Saito Sho, Hayakawa Kayoko, Hashimoto Masao, Takasaki Jin, Ohmagari Norio
Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.
Department of Respirology, National Center for Global Health and Medicine, Japan.
Jpn J Infect Dis. 2021 Mar 24;74(2):161-165. doi: 10.7883/yoken.JJID.2020.531. Epub 2020 Aug 31.
Real-time reverse transcription polymerase chain reaction (RT-PCR) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are occasionally repeated when clinicians suspect false-negative results, but the conditions under which repeated RT-PCR testing is warranted remain unclear. We evaluated the practice of repeat RT-PCR testing for SARS-CoV-2 in 45 patients who were retested after an initial negative PCR test. Of these, the diagnosis of coronavirus disease (COVID-19) was confirmed in four patients with typical chest computed tomography (CT) findings and in one patient without typical CT findings in whom the test result was strongly suspected to be false-positive. We recommend repeat RT-PCR testing only for patients with typical CT findings of COVID-19.
当临床医生怀疑严重急性呼吸综合征冠状病毒2（SARS-CoV-2）实时逆转录聚合酶链反应（RT-PCR）检测结果为假阴性时，偶尔会重复进行检测，但重复RT-PCR检测的必要条件仍不明确。我们评估了45例最初PCR检测呈阴性后再次检测的患者中重复进行SARS-CoV-2 RT-PCR检测的情况。其中，4例具有典型胸部计算机断层扫描（CT）表现的患者以及1例无典型CT表现但检测结果高度怀疑为假阳性的患者被确诊为冠状病毒病（COVID-19）。我们建议仅对具有COVID-19典型CT表现的患者进行重复RT-PCR检测。
