Department of Neurology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.
Department of Biochemistry, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.
Angiology. 2021 Oct;72(9):850-854. doi: 10.1177/00033197211012135. Epub 2021 Apr 27.
Silent brain infarction (SBI) has been considered as a subclinical risk factor for symptomatic possible future stroke. We investigated the association between serum inflammatory markers and SBI. Patients (n = 54) diagnosed with SBI as the study group and 52 individuals as the control group were included in this study. Silent brain infarction is defined as a hyperintense lesion that was ≥3 mm in 1 dimension on fluid-attenuated inversion recovery T2-weighted magnetic resonance image, if the patient had normal neurological examination or had an abnormality that was not consistent with the brain lesion locations, after being evaluated by a neurologist. Serum endocan levels ( = .036) and high-sensitivity C-reactive protein (hsCRP; = .022) were significantly higher in patients with SBI than the controls. Pentraxin 3, erythrocyte sedimentation rate, white blood count, lymphocyte, monocyte, neutrophil, low-density lipoprotein, and triglyceride levels were not significantly different when comparing the groups with and without SBI. There was a significant correlation ( = -0.196; = .16) between hsCRP and endocan levels in the SBI group. Endocan, a novel biomarker of endothelial pathology, was significantly increased in patients with SBI and may be useful to predict the future risk of stroke.
无症状性脑梗死 (SBI) 被认为是症状性未来卒中的亚临床危险因素。我们研究了血清炎症标志物与 SBI 之间的关系。将诊断为 SBI 的患者（n = 54）作为研究组，将 52 名个体作为对照组纳入本研究。无症状性脑梗死的定义为：如果患者的神经系统检查正常，或异常情况与脑病变部位不一致，经神经科医生评估后，在液体衰减反转恢复 T2 加权磁共振图像上，病灶呈高信号，且长度≥3mm。与对照组相比，SBI 患者的血清内脂素水平（ =.036）和高敏 C 反应蛋白（hsCRP； =.022）显著升高。比较 SBI 组和无 SBI 组时，五聚素 3、红细胞沉降率、白细胞计数、淋巴细胞、单核细胞、中性粒细胞、低密度脂蛋白和甘油三酯水平无显著差异。SBI 组 hsCRP 和内脂素水平呈显著负相关（ = -0.196； =.16）。作为内皮病理的新型生物标志物，内脂素在 SBI 患者中显著升高，可能有助于预测未来的卒中风险。
