Department of Internal Medicine, Faculty of Medicine (Girls) Al-Azhar University, Cairo, Egypt.
Department of Biochemistry, Faculty of Medicine Al Azhar University, Faculty of Medicine (Girls) Al-Azhar University, Cairo, Egypt.
Int J Clin Pract. 2022 Jul 13;2022:4524637. doi: 10.1155/2022/4524637. eCollection 2022.
HD and CKD groups had significantly higher endocan levels when compared with control group (median (IQR): 519.0 (202.3-742.0) versus 409.0 (245.3-505.3) and 273.0 (168.0-395.5) ng/L, respectively). Also, HD patients had significantly higher endocan levels when compared with CKD levels. HD patients had significantly higher carotid intima-media thickness (CIMT) when compared with CKD patients (median (IQR): 0.80 (0.80-0.90) versus 0.75 (0.73-0.75) mm, < 0.001). HD patients had significantly higher frequency of SCA when compared with CKD patients (46.7% versus 13.3%, =0.005). Patients with SCA had significantly higher hsCRP (median (IQR): 36.5 (26.8-43.5) versus 24.0 (15.8-29.0) mg/dl) and endocan levels (697.0 (528.3-974.8) versus 222.5 (158.8-565.8) ng/L) when compared with patients without SCA. ROC curve analysis of endocan for identification of SCA in HD patients showed that at a cutoff of 380.5 ng/L, endocan has an AUC of 0.862 with a sensitivity and specificity of 92.9% and 68.7%, respectively.
Serum endocan levels are related to SCA in HD patients. In addition, it is associated with the hyperinflammatory state in those patients.
与对照组相比，HD 和 CKD 组的内皮素水平明显升高（中位数（IQR）：519.0（202.3-742.0）比 409.0（245.3-505.3）和 273.0（168.0-395.5）ng/L）。此外，与 CKD 患者相比，HD 患者的内皮素水平明显升高。与 CKD 患者相比，HD 患者的颈动脉内膜中层厚度（CIMT）明显更高（中位数（IQR）：0.80（0.80-0.90）比 0.75（0.73-0.75）mm，<0.001）。与 CKD 患者相比，HD 患者的 SCA 发生率明显更高（46.7%比 13.3%，=0.005）。与无 SCA 的患者相比，SCA 患者的 hsCRP（中位数（IQR）：36.5（26.8-43.5）比 24.0（15.8-29.0）mg/dl）和内皮素水平（697.0（528.3-974.8）比 222.5（158.8-565.8）ng/L）明显更高。ROC 曲线分析显示，内皮素用于识别 HD 患者的 SCA 时，其截断值为 380.5ng/L，AUC 为 0.862，敏感性和特异性分别为 92.9%和 68.7%。
血清内皮素水平与 HD 患者的 SCA 有关。此外，它与这些患者的高炎症状态有关。
