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Glypicans 基因表达在肝细胞癌患者中的诊断和预后价值不同。

Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma.

机构信息

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Road 6#, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

Department of General Surgery, Shenzhen Children's Hospital, Yi Tian Road 7019#, Shenzhen, 518026, Guangdong Province, People's Republic of China.

出版信息

BMC Cancer. 2021 Apr 26;21(1):462. doi: 10.1186/s12885-021-08104-z.

DOI:10.1186/s12885-021-08104-z
PMID:33902495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8073913/
Abstract

BACKGROUD

In our current work, we aimed to investigate the expressions of glypican (GPC) family genes at the mRNA level and assess their prognostic significances in patients with hepatocellular carcinoma (HCC).

METHODS

The pathological roles of GPC family genes were examined using bioinformatics analysis. The diagnostic values of GPC genes were explored with the Gene Expression Profiling Interactive Analysis. Moreover, the mRNA expression and prognostic values of GPC genes were assessed via the KM plotter database.

RESULTS

Our data showed that the expression of GPC-3 was dramatically increased in the liver tumor tissue. Moreover, the expressions of the other five GPC family members were not significantly different between the tumor and normal liver tissues (P > 0.05). Furthermore, the up-regulation of GPC-1 at the mRNA level was dramatically correlated to the reduced overall survival (OS) for all HCC patients (hazard ratio = 2.03, 95% confidence intervals =1.44-2.87, P = 4.1e-05) compared with its low-expression group. Besides, the prognosis of the Caucasians was related to most GPC family genes, while the prognosis of the Asian race was only related to the expression of GPC-2. Besides, for pathological factors, including stage, grade, AJCC, and vascular invasion, the higher the pathological grade and vascular invasiveness, the lower the expression levels of GPC family genes (P < 0.05). Finally, the expression levels of GPC-1, 2, and 3 in the hepatitis group were related to the poor prognosis of HCC in the risk factor (alcohol consumption and hepatitis) subgroup (P < 0.05).

CONCLUSIONS

Our findings indicated that GPC-3 was dysregulated in HCC compared with paracancerous tissues. The expression of GPC-1 could be used as a potent predictive index for the general prognosis of HCC. The pathology, patients, and risk factors might affect the prognostic value of GPC family genes in HCC.

摘要

背景

在我们目前的工作中，我们旨在研究糖蛋白（GPC）家族基因在mRNA 水平上的表达，并评估它们在肝细胞癌（HCC）患者中的预后意义。

方法

使用生物信息学分析研究 GPC 家族基因的病理作用。通过 Gene Expression Profiling Interactive Analysis 探索 GPC 基因的诊断价值。此外，通过 KM plotter 数据库评估 GPC 基因的 mRNA 表达和预后价值。

结果

我们的数据显示，GPC-3 的表达在肝肿瘤组织中显著增加。此外，其他五个 GPC 家族成员在肿瘤和正常肝组织之间的表达没有显著差异（P > 0.05）。此外，GPC-1 在 mRNA 水平的上调与所有 HCC 患者的总生存（OS）显著降低相关（危险比=2.03，95%置信区间=1.44-2.87，P=4.1e-05）与低表达组相比。此外，高加索人的预后与大多数 GPC 家族基因有关，而亚洲人的预后仅与 GPC-2 的表达有关。此外，对于病理因素，包括分期、分级、AJCC 和血管侵犯，病理分级和血管侵犯越高，GPC 家族基因的表达水平越低（P < 0.05）。最后，在危险因素（饮酒和肝炎）亚组中，肝炎组中 GPC-1、2 和 3 的表达水平与 HCC 的不良预后相关（P < 0.05）。

结论

我们的研究结果表明，与癌旁组织相比，GPC-3 在 HCC 中失调。GPC-1 的表达可以作为 HCC 总体预后的有效预测指标。病理学、患者和危险因素可能影响 GPC 家族基因在 HCC 中的预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/58267c2afa09/12885_2021_8104_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/faf6894fbef9/12885_2021_8104_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/991ce8ffaa5b/12885_2021_8104_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/22e90379391a/12885_2021_8104_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/451e15c790d7/12885_2021_8104_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/51cae3675b5a/12885_2021_8104_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/88f4ae622510/12885_2021_8104_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/35a8c1c746e5/12885_2021_8104_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/dc6c814970fe/12885_2021_8104_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/58267c2afa09/12885_2021_8104_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/faf6894fbef9/12885_2021_8104_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/991ce8ffaa5b/12885_2021_8104_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/22e90379391a/12885_2021_8104_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/451e15c790d7/12885_2021_8104_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/51cae3675b5a/12885_2021_8104_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/88f4ae622510/12885_2021_8104_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/35a8c1c746e5/12885_2021_8104_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/dc6c814970fe/12885_2021_8104_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/279b/8073913/58267c2afa09/12885_2021_8104_Fig9_HTML.jpg

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Hum Pathol. 2021 Jun;112:86-101. doi: 10.1016/j.humpath.2020.12.009. Epub 2020 Dec 30.
2
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J Histochem Cytochem. 2020 Dec;68(12):841-862. doi: 10.1369/0022155420933709. Epub 2020 Jul 6.
3
Epidemiology and surveillance for hepatocellular carcinoma: New trends.肝癌的流行病学和监测：新趋势。
泛癌症分析及 GPC1 在肝细胞癌中的致癌作用。
Sci Rep. 2024 Jul 9;14(1):15870. doi: 10.1038/s41598-024-66838-9.
4
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Front Cell Dev Biol. 2023 Jul 18;11:1157841. doi: 10.3389/fcell.2023.1157841. eCollection 2023.
5
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Medicina (Kaunas). 2022 Dec 30;59(1):86. doi: 10.3390/medicina59010086.
6
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Front Oncol. 2022 Sep 23;12:1012418. doi: 10.3389/fonc.2022.1012418. eCollection 2022.
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