Wang Sen, Qiu Yudong, Bai Bing
Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Front Oncol. 2019 Jul 12;9:614. doi: 10.3389/fonc.2019.00614. eCollection 2019.
Glypican-1 (GPC-1) and other glypicans are a family of heparan sulfate proteoglycans. These proteins are highly expressed on the cell membrane and in the extracellular matrix, functioning mainly as modulators of growth factor signaling. Some of them are abnormally expressed in cancer, possibly involved in tumorigenesis, and detectable in blood as potential clinical biomarkers. GPC-1 is another glypican member that has been found to be associated with some cancers, and has increasingly interested the cancer field. Here we provide a brief review about GPC-1 in its expression, signaling and potential as a cancer biomarker.
磷脂酰肌醇蛋白聚糖-1（GPC-1）及其他磷脂酰肌醇蛋白聚糖是硫酸乙酰肝素蛋白聚糖家族的成员。这些蛋白质在细胞膜和细胞外基质中高度表达，主要作为生长因子信号的调节剂发挥作用。其中一些在癌症中异常表达，可能参与肿瘤发生，并且在血液中可检测到，作为潜在的临床生物标志物。GPC-1是另一种已被发现与某些癌症相关的磷脂酰肌醇蛋白聚糖成员，并且越来越受到癌症领域的关注。在此，我们简要综述GPC-1在其表达、信号传导以及作为癌症生物标志物的潜力方面的研究。
