糖蛋白聚糖在癌症进展和治疗中的作用。
The Role of Glypicans in Cancer Progression and Therapy.
机构信息
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
出版信息
J Histochem Cytochem. 2020 Dec;68(12):841-862. doi: 10.1369/0022155420933709. Epub 2020 Jul 6.
Abstract
Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple ligands, including morphogens, growth factors, chemokines, ligands, receptors, and components of the extracellular matrix through their heparan sulfate chains and core protein. Therefore, glypicans can function as coreceptors to regulate cell proliferation, cell motility, and morphogenesis. In addition, some glypicans are abnormally expressed in cancers, possibly involved in tumorigenesis, and have the potential to be cancer-specific biomarkers. Here, we provide a brief review focusing on the expression of glypicans in various cancers and their potential to be targets for cancer therapy.
摘要
黏蛋白是一类通过糖基磷脂酰肌醇锚定连接到细胞膜上的硫酸乙酰肝素蛋白聚糖。黏蛋白通过其硫酸乙酰肝素链和核心蛋白与多种配体相互作用，包括形态发生素、生长因子、趋化因子、配体、受体和细胞外基质的成分。因此，黏蛋白可以作为辅助受体来调节细胞增殖、细胞迁移和形态发生。此外，一些黏蛋白在癌症中异常表达，可能参与肿瘤发生，并有可能成为癌症特异性的生物标志物。在这里，我们提供了一个简要的综述，重点介绍了黏蛋白在各种癌症中的表达及其作为癌症治疗靶点的潜力。
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