Center of Oncology of the Lublin Region St. John from Dukla, Jaczewski Street 7, 20-090, Lublin, Poland.
Chair and Department of Hygiene, Medical University of Lublin, Radziwillowska Street 11, 20-080, Lublin, Poland.
BMC Pharmacol Toxicol. 2021 Apr 26;22(1):21. doi: 10.1186/s40360-021-00490-1.
Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ß and tumor necrosis factorα (TNFα) in kidneys, livers and the function of these organs.
Thirty two female mice were used. They were divided into 4 groups: controls, mice receiving 1.61 mg/kg bifenthrin for 28 days (group 1), 4.025 mg/kg (2), 8.05 mg/kg (3). On day 29 they were sacrificed, blood, livers and kidneys were obtained. Creatinine concentration and alanine transaminase (ALT) activity were estimated in the blood sera. Interleukin1ß and TNFα concentrations in the organs were measured.
Mean interleukin 1ß concentration in the livers of controls was 53 pg/ml, in group 1- 54 pg/ml, 2- 59 pg/ml, 3- 99 pg/ml (p < 0.05 vs controls). It was accompanied by significant increase in ALT activity in group 3 vs controls (p < 0.05). In the control kidneys interleukin 1ß was 3.9 pg/ml, group 1-6.8 pg/ml, 2-9.8 pg/ml and 3- 11 pg/ml. Statistically significant difference between group 1, 2 and 3 vs controls was found. There was no significant differences among the groups in TNFα concentrations neither in the livers nor kidneys.
Subacute poisoning with bifenthrin significantly increases interleukin 1ß concentration in livers and kidneys in a dose-proportionate level. It is accompanied by ALT activity increase. It confirms nephrotoxic and hepatotoxic and pro-inflammatory effect of bifenthrin in non-target organisms.
联苯菊酯是一种拟除虫菊酯。人类慢性接触这种杀虫剂的情况时有发生。有关拟除虫菊酯的免疫毒性和促炎作用的报道已经发表。本文的目的是检查亚急性联苯菊酯中毒是否会影响肾脏、肝脏中的促炎细胞因子白细胞介素 1β和肿瘤坏死因子α（TNFα）以及这些器官的功能。
使用 32 只雌性小鼠。将它们分为 4 组：对照组、接受 1.61mg/kg 联苯菊酯 28 天的小鼠（第 1 组）、4.025mg/kg（第 2 组）和 8.05mg/kg（第 3 组）。第 29 天处死它们，采集血液、肝脏和肾脏。测定血清中肌酐浓度和丙氨酸转氨酶（ALT）活性。测量器官中的白细胞介素 1β和 TNFα浓度。
对照组肝脏中白细胞介素 1β的平均浓度为 53pg/ml，第 1 组为 54pg/ml，第 2 组为 59pg/ml，第 3 组为 99pg/ml（p<0.05 与对照组相比）。同时，第 3 组的 ALT 活性与对照组相比显著增加（p<0.05）。在对照组肾脏中，白细胞介素 1β为 3.9pg/ml，第 1 组为 6.8pg/ml，第 2 组为 9.8pg/ml，第 3 组为 11pg/ml。第 1、2 和 3 组与对照组之间存在统计学显著差异。在肝脏和肾脏中，各组之间 TNFα浓度均无显著差异。
亚急性联苯菊酯中毒会显著增加肝脏和肾脏中白细胞介素 1β的浓度，呈剂量依赖性。它伴随着 ALT 活性的增加。它证实了联苯菊酯在非靶标生物中具有肾毒性、肝毒性和促炎作用。
