ABO 和 RhD 血型与表型全基因组疾病风险之间关联的非信仰研究。

An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk.

机构信息

Hematology Department, Karolinska University Hospital, Stockholm, Sweden.

Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.

出版信息

Elife. 2021 Apr 27;10:e65658. doi: 10.7554/eLife.65658.

BACKGROUND

There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted.

METHODS

Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modeled outcomes for 1217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals.

RESULTS

We discovered 49 and 1 associations between a disease and ABO and RhD blood groups, respectively, after adjustment for multiple testing. We identified new associations such as a decreased risk of kidney stones and blood group B as compared to blood group O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood groups A and AB as compared to blood group O and RhD positive as compared to negative.

CONCLUSIONS

Our findings generate strong further support for previously known associations, but also indicate new interesting relations.

FUNDING

Swedish Research Council.

背景

ABO 和 RhD 血型与多种疾病之间存在多种已知关联。目前尚未开展过基于人群的系统研究，以阐明大量疾病类别与血型之间的关联。

方法

我们使用全面的全国性献血输血数据库 SCANDAT3-S，对包括 510 万人在内的 7000 万人年随访资料中 1217 种疾病类别的结果进行建模。

结果

在进行多次检验调整后，我们发现疾病与 ABO 和 RhD 血型之间分别存在 49 种和 1 种关联。我们发现了新的关联，例如与血型 O 相比，血型 B 发生肾结石的风险降低。我们还扩展了之前关于其他关联的知识，例如与血型 O 相比，妊娠高血压与血型 A 和 AB 有关，与 RhD 阴性相比，RhD 阳性也与妊娠高血压有关。