Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Magn Reson Imaging Clin N Am. 2021 May;29(2):163-183. doi: 10.1016/j.mric.2021.02.001.
This article reviews diseases for which persistent signal abnormalities on diffusion-weighted imaging are the key to their diagnosis. Specifically, updated knowledge regarding the neuroimaging patterns of the following diseases is summarized: sporadic Creutzfeldt-Jakob disease, neuronal intranuclear inclusion disease, and hereditary diffuse leukoencephalopathy with axonal spheroids-colony-stimulating factor receptors/adult-onset leukoencephalopathy with axonal spheroids and pigmented glia. In addition, their differential diagnoses; clinical manifestations; and pathologic, genetic, and imaging correlates are discussed.
本文综述了在弥散加权成像上存在持续信号异常的疾病，这些异常是其诊断的关键。具体而言，总结了以下疾病的神经影像学模式的最新知识：散发性克雅氏病、神经元核内包涵体病和伴有轴索性球体的遗传性弥漫性白质脑病伴轴索性球体和色素性神经胶质、集落刺激因子受体/伴有轴索性球体和色素性神经胶质的成人发病型白质脑病。此外，还讨论了它们的鉴别诊断、临床表现以及病理、遗传和影像学相关性。
