Mallet E, Basuyau J P, Le Luyer B, de Menibus C H
Service de Pédiatrie, C.H.R.U. Ch. Nicolle, Rouen.
Allerg Immunol (Paris). 1988 Jan;20(1):11-2, 14.
The serum IgE, that are associated to the process of the immediate allergy are studied in children presenting a clinical semiology suggestive of intolerance to the cow-milk proteins, in order to specify their contribution in the diagnosis and the follow-up of this disease. The serum IgE are determined by the PRIST method and the presence of the milk proteins specific IgE, by the RAST method. In infants (n = 80) fed with infant formula and less than 4 months old, if it obviously appeared an increase of the global IgE with the age, on the other hand, no one had specific IgE to the cow-milk proteins. The same methods were used in children presenting a clinical semiology of IPLV. It appeared these children could be separated in 2 groups according to the presence or the absence of extra-digestive symptoms (urticaria...). There is significant increase of the global IgE level and the first group, but not in the second one. The two main allergens more frequently implicated are the alpha-lactalbumin and the beta lactaglobulin. Meanwhile the RAST efficiency is better for the global allergen to the cow-milk. Meanwhile, the determination of the specific IgE to the milk PLV does not present a prognosis interest. In fact, the success of a milk proteins reintroduction is not necessarily correlated with a previous negativation of RAST.
对有提示牛奶蛋白不耐受临床症状的儿童，研究与速发型过敏过程相关的血清IgE，以明确其在该疾病诊断和随访中的作用。血清IgE通过PRIST法测定，牛奶蛋白特异性IgE的存在通过RAST法测定。在80名4个月以下以婴儿配方奶粉喂养的婴儿中，尽管总IgE明显随年龄增加，但无人对牛奶蛋白有特异性IgE。对有IPLV临床症状的儿童采用同样方法。根据有无消化外症状（荨麻疹等），这些儿童可分为两组。第一组总IgE水平显著升高，第二组则不然。最常涉及的两种主要变应原是α-乳白蛋白和β-乳球蛋白。同时，RAST对牛奶总变应原的检测效率更高。同时，测定牛奶PLV特异性IgE并无预后意义。事实上牛奶蛋白重新引入的成功与否不一定与之前RAST结果为阴性相关。
