Kawasaki S, Takeda K, Tanabe S, Nakata T, Hayashi J, Oguro M, Suzuka T, Nakamura Y, Lee L C, Sasaki S
Second Department of Internal Medicine, Kyoto Prefectural University, Japan.
Am J Hypertens. 1988 Jul;1(3 Pt 1):291-3. doi: 10.1093/ajh/1.3.291.
To determine whether baroreflex can affect the norepinephrine system in the hypothalamus, the extracellular concentration of norepinephrine were measured by the brain dialysis technique in sinoaortic denervated rats (SAD). Twenty-four hours after sinoaortic denervation, systolic blood pressure and heart rate were significantly elevated, and norepinephrine concentration in perfusate of the posterior hypothalamus was significantly higher in SAD rats than in sham-operated rats. These results suggest that baroreflex could modify the activity of noradrenergic neuron projecting to the posterior hypothalamus.
为了确定压力感受性反射是否会影响下丘脑的去甲肾上腺素系统，采用脑透析技术测量了去窦主动脉神经大鼠（SAD）下丘脑细胞外去甲肾上腺素浓度。去窦主动脉神经24小时后，收缩压和心率显著升高，SAD大鼠下丘脑后部灌流液中的去甲肾上腺素浓度显著高于假手术大鼠。这些结果表明，压力感受性反射可改变投射至下丘脑后部的去甲肾上腺素能神经元的活性。
