Shields J A, Shields C L, Shakin E P, Kobetz L E
Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107.
Br J Ophthalmol. 1988 Jun;72(6):456-60. doi: 10.1136/bjo.72.6.456.
A 52-year-old woman was found to have a small juxtapapillary pigmented lesion in the choroid of the left eye. This lesion remained clinically stationary for one year, but subsequent growth prompted enucleation of the eye. The tumour was diagnosed histologically as a choroidal malignant melanoma of mixed cell type. Approximately 52 months later the patient developed proptosis of the contralateral (right) eye. Orbital ultrasonography showed a large mass in the right orbit, which was confirmed by needle biopsy to be a melanoma. In addition the patient was found to have metastatic melanoma to the choroid, right lower eyelid area, and liver. The development of simultaneous orbital, choroidal, and eyelid metastases from a contralateral choroidal melanoma is of ophthalmic interest and appears to be unique.
一名52岁女性被发现左眼脉络膜有一个小的乳头旁色素沉着病变。该病变在临床上保持稳定一年，但随后的生长促使眼球摘除。组织学诊断该肿瘤为混合细胞型脉络膜恶性黑色素瘤。大约52个月后，患者对侧（右）眼出现眼球突出。眼眶超声检查显示右眼眶有一个大肿块，针吸活检证实为黑色素瘤。此外，还发现该患者脉络膜、右下眼睑区域和肝脏有转移性黑色素瘤。对侧脉络膜黑色素瘤同时发生眼眶、脉络膜和眼睑转移的情况在眼科领域值得关注，且似乎是独一无二的。
