Department of Pathophysiology, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland; Department of Nephrology, Transplantology and Internal Medicine, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland.
Department of Nephrology, Transplantology and Internal Medicine, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland
Pol Arch Intern Med. 2021 Jun 29;131(6):512-519. doi: 10.20452/pamw.15974. Epub 2021 Apr 27.
INTRODUCTION Sleep disturbances, similarly to constipation‑related symptoms, are common problems in patients with chronic kidney disease (CKD) and are associated with worse health-related quality of life. OBJECTIVES The aim of the study was to investigate sleep problems in conservatively treated patients with CKD and to assess association between sleep quality and constipation in that population. PATIENTS AND METHODS In this cross‑sectional study, 100 conservatively treated outpatients with CKD filled questionnaires addressing sleep quality (The Medical Outcomes Study 12‑item Sleep Scale-Revised [MOS‑Sleep‑R]) and constipation‑related symptoms (PAC‑SYM, Rome III criteria). RESULTS The T scores of none of the assessed sleep domains differed across the estimated glomerular filtration rate terciles (all P >0.05). The scores from the PAC-SYM abdominal and stool subscales correlated with all assessed sleep quality domains. In both univariable and multivariable regression models adjusted for key clinical data, functional constipation, less than 7 bowel movements a week, abdominal discomfort, and pain as well as too small bowel movements were independently associated with increased prevalence ratio of decreased sleep quality. CONCLUSIONS In patients with nondialysis CKD, sleep disorders might have common etiological factors with constipation-related symptoms.
简介
睡眠障碍与与便秘相关的症状一样，在慢性肾脏病（CKD）患者中很常见，并且与较差的健康相关生活质量相关。
目的
本研究旨在探讨保守治疗的 CKD 患者的睡眠问题，并评估该人群中睡眠质量与便秘之间的关系。
患者与方法
在这项横断面研究中，100 名接受保守治疗的 CKD 门诊患者填写了调查问卷，涉及睡眠质量（医疗结果研究 12 项睡眠量表修订版[MOS-Sleep-R]）和与便秘相关的症状（PAC-SYM，罗马 III 标准）。
结果
在估计肾小球滤过率三分位组中，所有评估的睡眠域的 T 评分均无差异（均 P >0.05）。PAC-SYM 腹部和粪便子量表的评分与所有评估的睡眠质量域相关。在调整了关键临床数据的单变量和多变量回归模型中，功能性便秘、每周少于 7 次排便、腹部不适和疼痛以及粪便量过少与睡眠质量下降的患病率比增加独立相关。
结论
在非透析 CKD 患者中，睡眠障碍可能与便秘相关症状有共同的病因。
