查拉西迪德 B 的提议结构的全合成。

Total Synthesis of the Proposed Structure of Characellide B.

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Org Lett. 2021 May 7;23(9):3680-3684. doi: 10.1021/acs.orglett.1c01066. Epub 2021 Apr 27.

DOI:10.1021/acs.orglett.1c01066

PMID:33904744

Abstract

We achieved the total synthesis of the proposed structure of characellide B, a novel lipoglycotripeptide. Comparison of the data for the synthetic compound with those for the natural product indicated some possible errors in the original structural assignment. Furthermore, we synthesized the other four stereoisomers, focusing on the d-Asp-d--Thr fragment, to determine the actual structure of characellide B. Nevertheless, the data for the stereoisomers were not consistent with those for the natural product.

摘要

我们成功地全合成了 characellide B 的提议结构，这是一种新型的脂糖三肽。比较合成化合物和天然产物的数据表明，原始结构分配中可能存在一些错误。此外，我们合成了另外四个立体异构体，重点是 d-Asp-d--Thr 片段，以确定 characellide B 的实际结构。然而，立体异构体的数据与天然产物的数据不一致。