Babar Javeria, Ahmad Sajjad, Parveen Bushra, Ali Kulsoom Ghulam, Mushtaq Aqsa, Zahoor Ameer Fawad, Ahmad Raheel, Mansha Asim, Irfan Ahmad
Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Department of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, 38000, Pakistan.
Top Curr Chem (Cham). 2025 Apr 26;383(2):20. doi: 10.1007/s41061-025-00504-0.
The Horner-Wadsworth-Emmons (HWE) reaction is a commonly used and reliable phenomenon for carbon-carbon olefination in organic chemistry, carried out by treating aldehyde or ketones with phosphonate esters to afford the substituted alkenes. HWE reaction has also been observed to be involved in the stereo-controlled syntheses of naturally occurring compounds that acquire pharmaceutical profiles against various diseases. In this article, recent implementations of Horner-Wadsworth-Emmons reaction towards the notable total syntheses of naturally occurring compounds such as polyketides have been summarized.
霍纳-沃兹沃思-埃蒙斯（HWE）反应是有机化学中用于碳-碳烯烃化的一种常用且可靠的反应，通过用膦酸酯处理醛或酮来得到取代烯烃。人们还观察到HWE反应参与了具有抗多种疾病药物特性的天然化合物的立体控制合成。在本文中，已总结了霍纳-沃兹沃思-埃蒙斯反应在天然化合物（如聚酮化合物）显著全合成中的最新应用。
