肺衰老的压力：内质网与衰老面对面。
The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête.
机构信息
University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD; University of Groningen, Department of Molecular Pharmacology, Groningen, The Netherlands.
出版信息
Physiology (Bethesda). 2021 May 1;36(3):150-159. doi: 10.1152/physiol.00039.2020.
Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.
除了结构变化，肺衰老的特征还包括内质网（ER）应激反应失调和衰老增加。据报道，香烟烟雾等因素会引起 ER 应激反应和衰老。因此，阐明 ER 和衰老途径相互作用的机制已成为一个挑战。在这篇综述中，我们重点介绍了已知和未知的 ER 应激反应和衰老及其在衰老肺部中的相互作用。
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