Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan.
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA.
Trends Endocrinol Metab. 2018 Jun;29(6):435-445. doi: 10.1016/j.tem.2018.03.008. Epub 2018 Apr 6.
Melatonin was discovered in the pineal gland and first came to be known as a biochemical synchronizer of circadian rhythm. The molecular mechanisms underlying the broad-spectrum actions of melatonin are not restricted to its interaction with proteins but it also has functional effects after influencing RNA species that have no protein-coding potential. In this review we discuss the current understanding of the melatonin-mediated modulation of noncoding RNA (ncRNA) pathways under different physiological and pathological conditions. We also delineate the impact of specific ncRNAs in controlling the synthesis of melatonin. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin and to better explore the emerging functions of the noncoding transcriptome.
褪黑素最初在松果腺中被发现，最初被认为是昼夜节律的生化同步器。褪黑素广谱作用的分子机制不仅限于其与蛋白质的相互作用，而且在影响没有蛋白质编码潜力的 RNA 物种后也具有功能效应。在这篇综述中，我们讨论了目前对褪黑素介导的不同生理和病理条件下非编码 RNA(ncRNA)途径的调节的理解。我们还描述了特定 ncRNA 在控制褪黑素合成中的作用。本文汇编的信息将为制定未来关于褪黑素的机制研究的想法以及更好地探索非编码转录组的新兴功能提供坚实的基础。
