Sun Yanping, Zhang Yuping, Sun Minghao, Gao Wuyou, He Yujia, Wang Yu, Yang Bingyou, Kuang Haixue
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, China.
Front Pharmacol. 2024 Aug 16;15:1421662. doi: 10.3389/fphar.2024.1421662. eCollection 2024.
(EU) is a precious tree species native to China originating during the ice age. This species has important economic value and comprehensive development potential, particularly in medicinal applications. The medicinal parts of EU are its bark () and leaves () which have been successively used as a traditional Chinese medicine to treat diseases since the first century BC. During the last 2 decades, as natural polysaccharides have become of increasing interest in pharmacology, biomedicine, cosmetic and food applications, more and more scholars have begun to study polysaccharides derived from EU as well. EU polysaccharides have been found to have a variety of biological functions both and , including immunomodulatory, antioxidant, anti-inflammatory, anticomplementary, antifatigue, and hepatoprotective activities. This review aims to summarize these recent advances in extraction, purification, structural characteristics, pharmacological activities and applications in different fields of EU bark and leaf polysaccharides. It was found that both polysaccharides and polysaccharides were suitable for medicinal use. may potentially be used to substitute for in terms of immunomodulation and antioxidant activities. This study serves as a valuable reference for improving the comprehensive utilization of EU polysaccharides and further promoting the application of EU polysaccharides.
杜仲是一种原产于中国的珍贵树种,起源于冰河时代。该树种具有重要的经济价值和综合开发潜力,尤其在药用方面。杜仲的药用部位是其树皮和树叶,自公元前一世纪以来,它们就先后被用作传统中药来治疗疾病。在过去的20年里,随着天然多糖在药理学、生物医学、化妆品和食品应用中越来越受到关注,越来越多的学者也开始研究杜仲衍生的多糖。杜仲多糖已被发现具有多种体内和体外生物学功能,包括免疫调节、抗氧化、抗炎、抗补体、抗疲劳和保肝活性。本综述旨在总结杜仲树皮和树叶多糖在提取、纯化、结构特征、药理活性及不同领域应用方面的这些最新进展。研究发现,杜仲树皮多糖和树叶多糖均适用于药用。在免疫调节和抗氧化活性方面,杜仲树叶多糖可能有潜力替代杜仲树皮多糖。本研究为提高杜仲多糖的综合利用率和进一步促进杜仲多糖的应用提供了有价值的参考。