Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.
Cancer Risk Appraisal and Prevention Branch, National Cancer Center, Goyang, Korea.
Epidemiol Health. 2021;43:e2021019. doi: 10.4178/epih.e2021019. Epub 2021 Mar 10.
Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea.
We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1).
During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis.
The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.
复发性呼吸道乳头瘤病（RRP）由人乳头瘤病毒（HPV）6 型和 11 型引起，通过接种疫苗可预防。本研究在韩国实施国家 HPV 疫苗接种计划之前，估计了青少年发病 RRP 的发病率。
我们使用强制性保险计划提供的索赔数据进行了一项队列研究，以估计 RRP 的发病率和相关的医疗保健使用情况。青少年 RRP 患者定义为年龄≤12 岁，有≥2 次住院或≥2 次门诊就诊，期间接受国际疾病分类，第 10 版喉良性肿瘤（D14.1）编码。
在 2002 年至 2014 年期间，123 名儿童（74 名男孩和 49 名女孩）被诊断为 RRP。患者的平均随访时间为 6.5 人年。发病率估计为 0.30/100000 人年。中位诊断年龄为 4.0 岁（平均 4.3 岁）。36 名（29.3%）患者接受了手术，其中 23 名（18.7%）患者接受了 2 次或更多次手术。通过更频繁的手术和连续手术之间更短的时间间隔来衡量严重疾病，与更年轻的诊断年龄相关。
韩国青少年发病 RRP 的估计发病率与其他国家报告的发病率相似。应继续使用国家健康保险服务索赔数据监测 RRP 负担。
