Carifi Marco, Napolitano Domenico, Morandi Morando, Dall'Olio Danilo
Department of Otolaryngology, Azienda Ospedaliera di Rilievo Nazionale A Cardarelli, Naples, Italy.
Department of Otolaryngology, Ospedale Maggiore CA Pizzardi, Bologna, Italy.
Ther Clin Risk Manag. 2015 May 5;11:731-8. doi: 10.2147/TCRM.S81825. eCollection 2015.
Although recurrent respiratory papillomatosis is a benign disease of the upper aerodigestive tract caused by infection with human papillomavirus, the disease process is unpredictable, ranging from mild disease and spontaneous remission to an aggressive disease with pulmonary spread and requirement for frequent surgical debulking procedures. It can present a protracted clinical course and cause potentially life-threatening compromise of the airways. Over recent decades, a number of alternative medical therapies to standard surgical treatment have been investigated, with modest outcomes overall. Currently, some additional therapies are being explored, together with novel surgical instrumentation that can help to avoid inevitable long-term stenotic complications, ultimately affecting quality of life. Hopefully, clinicians might soon be able to significantly improve the quality of treatment and outcomes for patients affected with recurrent respiratory papillomatosis, with human papillomavirus vaccination having a potentially important role.
尽管复发性呼吸道乳头状瘤病是一种由人乳头瘤病毒感染引起的上气道消化道良性疾病，但疾病进程难以预测，范围从轻度疾病和自发缓解到具有肺部扩散且需要频繁进行手术减瘤操作的侵袭性疾病。它可能呈现出迁延的临床病程，并导致气道出现潜在的危及生命的损害。在最近几十年里，人们对一些替代标准手术治疗的医学疗法进行了研究，总体结果一般。目前，正在探索一些额外的疗法，以及能够有助于避免不可避免的长期狭窄并发症（最终影响生活质量）的新型手术器械。有望临床医生很快能够显著改善复发性呼吸道乳头状瘤病患者的治疗质量和治疗结果，人乳头瘤病毒疫苗接种可能会发挥重要作用。
