Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):6610-6614. doi: 10.1080/14767058.2021.1918093. Epub 2021 Apr 27.
Many very preterm infants are treated with phototherapy (PT) for hyperbilirubinemia and it has been reported that PT can negatively affect gut perfusion. Thus, our aim was to evaluate the occurrence of feeding intolerance in the course of PT in these patients.
We retrospectively studied infants born at 25-31weeks from November 2017 to April 2020 who required PT during the first two weeks of life. Patients were used as their own controls recording for each one the occurrence of feeding intolerance after starting PT and the resumption of feeding tolerance after its termination.
We studied 125 preterm infants of whom 58 (46%) developed a feeding intolerance which disappeared in 47 (81%) of them at the end of PT. Regression analysis showed a trend toward a not significant decrease of risk of feeding intolerance in infants with higher birth weight and age at the start of the first course of PT.
We found that about half of our patients developed a transient feeding intolerance during PT that ceased in the vast majority of them after termination of the therapy. Further studies are necessary to confirm the correlation between PT and feeding intolerance.
许多极早产儿因高胆红素血症接受光疗（PT）治疗，有报道称 PT 可能会对肠道灌注产生负面影响。因此，我们的目的是评估这些患者在 PT 过程中喂养不耐受的发生情况。
我们回顾性研究了 2017 年 11 月至 2020 年 4 月期间出生于 25-31 周的婴儿，他们在生命的前两周需要接受 PT。为每个患者记录开始 PT 后发生喂养不耐受的情况，以及在 PT 结束后恢复喂养耐受的情况。
我们研究了 125 名早产儿，其中 58 名（46%）出现喂养不耐受，其中 47 名（81%）在 PT 结束时消失。回归分析显示，起始 PT 时体重较高和年龄较大的婴儿发生喂养不耐受的风险呈下降趋势，但无统计学意义。
我们发现，我们的患者中有一半左右在 PT 期间出现了短暂的喂养不耐受，其中绝大多数在治疗结束后消失。需要进一步的研究来证实 PT 和喂养不耐受之间的相关性。
