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N末端B型利钠肽原与常规临床危险因素作为血糖异常人群心血管事件或死亡预测指标的比较——来自ORIGIN试验的简要报告

NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia - A brief report from the ORIGIN trial.

作者信息

Wijkman Magnus O, Claggett Brian L, Pfeffer Marc A, Paré Guillaume, McQueen Matthew, Hess Sibylle, Lee Shun Fu, Gerstein Hertzel C

机构信息

Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden.

Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

出版信息

J Diabetes Complications. 2021 Jul;35(7):107928. doi: 10.1016/j.jdiacomp.2021.107928. Epub 2021 Apr 16.

Abstract

In patients with diabetes and cardiovascular or renal comorbidities, circulating levels of the N-terminal fragment of prohormone B-type natriuretic peptide (NT-proBNP) have similar discriminatory ability as multivariate models for prediction of cardiovascular events or death. We validated this finding in patients with dysglycemia not selected for co-existing cardiorenal diseases.

摘要

在患有糖尿病以及心血管或肾脏合并症的患者中,激素原B型利钠肽(NT-proBNP)的N端片段的循环水平与预测心血管事件或死亡的多变量模型具有相似的判别能力。我们在未因并存心肾疾病而被挑选的血糖异常患者中验证了这一发现。

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