Hayat Hasaan, Hayat Hanaan, Dwan Bennett Francis, Gudi Mithil, Bishop Jack Owen, Wang Ping
Precision Health Program, Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Lyman Briggs College, Michigan State University, East Lansing, MI, USA.
Onco Targets Ther. 2021 Apr 20;14:2761-2772. doi: 10.2147/OTT.S260391. eCollection 2021.
The properties of cancer stem cells (CSCs) have recently gained attention as an avenue of intervention for cancer therapy. In this review, we highlight some of the key roles of CSCs in altering the cellular microenvironment in favor of cancer progression. We also report on various studies in this field which focus on transformative properties of CSCs and their influence on surrounding cells or targets through the release of cellular cargo in the form of extracellular vesicles. The findings from these studies encourage the development of novel interventional therapies that can target and prevent cancer through efficient, more effective methods. These methods include targeting immunosuppressive proteins and biomarkers, promoting immunization against tumors, exosome-mediated CSC conversion, and a focus on the quiescent properties of CSCs and their role in cancer progression. The resulting therapeutic benefit and transformative potential of these novel approaches to stem cell-based cancer therapy provide a new direction in cancer treatment, which can focus on nanoscale, molecular properties of the cellular microenvironment and establish a more precision medicine-oriented paradigm of treatment.
癌症干细胞（CSCs）的特性最近作为癌症治疗的一种干预途径而受到关注。在本综述中，我们强调了CSCs在改变细胞微环境以促进癌症进展方面的一些关键作用。我们还报告了该领域的各种研究，这些研究聚焦于CSCs的转化特性及其通过以细胞外囊泡形式释放细胞货物对周围细胞或靶点的影响。这些研究结果鼓励开发新的干预疗法，这些疗法可以通过高效、更有效的方法靶向并预防癌症。这些方法包括靶向免疫抑制蛋白和生物标志物、促进肿瘤免疫、外泌体介导的CSC转化，以及关注CSCs的静止特性及其在癌症进展中的作用。这些基于干细胞的癌症治疗新方法所产生的治疗益处和转化潜力为癌症治疗提供了一个新方向，该方向可以聚焦于细胞微环境的纳米级分子特性，并建立一种更以精准医学为导向的治疗模式。
