Department of Nephrology, Hospital Clínic Barcelona, Barcelona, Spain.
Department of Medicine, University of Barcelona, Barcelona, Spain.
Artif Organs. 2021 Sep;45(9):E317-E323. doi: 10.1111/aor.13968. Epub 2021 May 20.
Toray has created a new generation of dialyzers, the polysulphone (TS) UL series, and polymethylmethacrylate (PMMA) NF-U series, which offer enhanced efficacy over the previous TS-S series and NF-H series. The aim of this study was to evaluate the safety and efficacy of these dialyzer series versus contrasted expanded hemodialysis (HDx) and postdilution hemodiafiltration (HDF). We conducted a prospective study in 12 patients. Each patient underwent six dialysis sessions: FX80 Cordiax in HD, Toraysulfone TS-1.8 UL in HD, Theranova 400 in HDx, polymethylmethacrylate (PMMA) NF-2.1 U in HDF, Toraysulfone TS-2.1 UL in HDF, and FX80 Cordiax in HDF. The removal ratios (RRs) of urea, creatinine, ß -microglobulin, myoglobin, prolactin, α -microglobulin, α -acid glycoprotein, and albumin were compared intraindividually. Dialysate albumin loss was also measured. The RRs for β -microglobulin, myoglobin, prolactin, α -microglobulin, and α -acid glycoprotein were higher with the TS-2.1 UL and FX80 Cordiax dialyzers in HDF than those obtained with HD treatments and NF-2.1 U in HDF. The β -microglobulin, myoglobin, and prolactin RRs were also higher with HDx than those obtained with HD treatments. The myoglobin and prolactin RRs were higher with TS-1.8 UL in HD than those obtained with helixone dialyzers in HD. Dialysate albumin loss was less than 3 g in all situations except in TS-2.1 UL in HDF. The highest global removal score values were obtained with the TS-2.1 UL and helixone dialyzers in HDF. Significant differences were found between all study situations. In conclusion, the new generation dialyzers, Toraysulfone TS Series UL and PMMA NF-U series, show excellent behaviour and tolerance in HD and HDF, representing an upgrade versus their predecessor series. The higher permeability of the TS UL series has been proven with higher efficiency in HD and maximum performance in HDF. The new PMMA NF-U series allows the use of HDF with good efficiency and complete safety.
东丽公司创造了新一代的透析器，聚砜（TS）UL 系列和聚甲基丙烯酸甲酯（PMMA）NF-U 系列，与之前的 TS-S 系列和 NF-H 系列相比，具有更高的疗效。本研究旨在评估这些透析器系列与对照的扩展血液透析（HDx）和后稀释血液透析滤过（HDF）相比的安全性和疗效。我们进行了一项前瞻性研究，纳入了 12 名患者。每位患者接受了 6 次透析：FX80 Cordiax 在 HD 中，Toraysulfone TS-1.8 UL 在 HD 中，Theranova 400 在 HDx 中，聚甲基丙烯酸甲酯（PMMA）NF-2.1 U 在 HDF 中，Toraysulfone TS-2.1 UL 在 HDF 中，FX80 Cordiax 在 HDF 中。比较了个体内尿素、肌酐、ß-微球蛋白、肌红蛋白、催乳素、α-微球蛋白、α-酸性糖蛋白和白蛋白的清除率（RR）。还测量了透析液白蛋白的损失。在 HDF 中，与 HD 治疗和 HDF 中的 NF-2.1 U 相比，TS-2.1 UL 和 FX80 Cordiax 透析器的 β-微球蛋白、肌红蛋白、催乳素、α-微球蛋白和 α-酸性糖蛋白 RR 更高。与 HD 治疗相比，HDx 中的 β-微球蛋白、肌红蛋白和催乳素 RR 更高。与 HD 中的 helixone 透析器相比，TS-1.8 UL 在 HD 中的肌红蛋白和催乳素 RR 更高。除了在 HDF 中的 TS-2.1 UL 中，所有情况下的透析液白蛋白损失均小于 3g。在 HDF 中，TS-2.1 UL 和 helixone 透析器的总体清除评分最高。所有研究情况之间均存在显著差异。总之，新一代透析器，聚砜 TS 系列 UL 和聚甲基丙烯酸甲酯 NF-U 系列，在 HD 和 HDF 中表现出良好的性能和耐受性，与前一系列相比有所升级。TS UL 系列的更高通透性已被证明在 HD 中具有更高的效率，在 HDF 中具有最大的性能。新型 PMMA NF-U 系列允许使用 HDF，具有良好的效率和完全的安全性。
