Centre for Clinical Veterinary Medicine, LMU Munich, Veterinärstrasse 13, 80539, Munich, Germany.
Small Animal Clinic, Oberhaching, Bajuwarenring 10, 80539, Munich, Germany.
Vet Dermatol. 2021 Jun;32(3):268-e74. doi: 10.1111/vde.12961. Epub 2021 Apr 27.
This article describes a case of multiple, recurrent, cutaneous inverted papillomas (CIPs) in a German shepherd dog, combined with a retrospective follow-up assessment of eight cases.
A 3-year-old, black, female German shepherd dog presented with four rapidly growing, alopecic, domed, hyperpigmented, shiny nodules, compatible with CIP. The dog was managed for pruritus, associated with atopic dermatitis, with long-term prednisolone therapy and this therapy was continued after the surgical excision. Twelve months after the initial presentation the dog was represented for two new CIP lesions, coinciding with an increased dosage of prednisolone during an allergic flare-up period.
Histopathological evaluation was conducted on both the original and subsequent lesions from the case with recurrence. Eight cases of CIP, based on histopathological findings, were identified retrospectively from the authors' diagnostic pathology service over the previous two years. All nine cases had lesions that exhibited varying degrees of inverted epithelial hyperplasia, multiple, endophytic, papillary epidermal projections, a cup-shaped base with central hyperkeratosis and active viral pathological findings (koilocytes). The submitting veterinarians were contacted and follow-up regarding recurrence and concurrent medications was obtained.
CIP is uncommonly reported, typically as a single lesion with no previous reports of recurrence, although one group of dogs with severe combined immunodeficiency developed invasive malignancies. In seven of eight retrospective cases no recurrence of CIP was recorded. The authors speculate that the recurrence in the German shepherd dog may have been associated with chronic (although low-dose) glucocorticoid administration.
本文描述了一只德国牧羊犬中多发性、复发性皮肤内翻性乳头状瘤（CIP）的病例，并对 8 例病例进行了回顾性随访评估。
一只 3 岁、黑色、雌性德国牧羊犬出现 4 个快速生长、脱毛、圆顶状、色素沉着过度、有光泽的结节，与 CIP 相符。由于特应性皮炎引起瘙痒，这只狗接受了长期的泼尼松龙治疗，并且在手术切除后继续进行该治疗。初次就诊后 12 个月，这只狗出现了 2 个新的 CIP 病变，与过敏发作期间泼尼松龙剂量增加同时发生。
对该复发病例的原始和后续病变进行了组织病理学评估。在过去两年中，作者的诊断病理学服务部门基于组织病理学发现，回顾性地确定了 8 例 CIP。所有 9 例病变均表现出不同程度的内翻性上皮增生、多发性、内生性、乳头状表皮突起、杯状基底伴中央角化过度和活跃的病毒病理学表现（空泡细胞）。联系了提交病例的兽医，并获得了关于复发和同时使用药物的随访信息。
CIP 报道较少，通常为单个病变，以前没有复发的报道，尽管一组患有严重联合免疫缺陷的狗发生了侵袭性恶性肿瘤。在 8 例回顾性病例中，有 7 例没有记录到 CIP 的复发。作者推测，德国牧羊犬的复发可能与慢性（尽管是低剂量）糖皮质激素治疗有关。
